[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.06.20.184Pharm Sci Asia 2021; 48(6), 516-522
 

Evaluation of aqueous and ethanol extracts of Cyperus rotundus L. on sexual behaviours and reproductive fitness in Drosophila melanogaster

Nattapong Wongchum1,2, Ananya Dechakhamphu3,4, Saran Chaweerak3, Somchai Pinlaor5, Alongklod Tanomtong1*

1 Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
2 Biology Program, Faculty of Science, Ubon Ratchathani Rajabhat University, Ubonratchathani, Thailand
3 Thai Traditional Medicine Program, Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubonratchathani, Thailand
4 Aesthetic Sciences and Health Program, Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubonratchathani, Thailand
5 Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand


Cyperus rotundus L. has been used in Ayurvedic and Egyptian folk medicine as an aphrodisiac, no experimental prove has been confirmed for this affirmation. In this study, we aimed to evaluate aqueous and ethanol extract of C. rotundus L. on sexual behaviors and reproductive fitness in Drosophila melanogaster. C. rotundus was extracts in water (WCE) and ethanolic (HECE). Their extracts were supplemented in diets in D. melanogaster. The results revealed that the 5 and 10 mg/mL HECE treatment significantly decreased the duration time of mating latency, significantly prolonged the copulation duration and produced the maximum number of eggs laying of Drosophila, particularly at 10 mg/mL HECE supplemented diet. Moreover, as to fertility, supplementation with 5 and 10 mg/mL HECE in Drosophila significantly increased the number of progenies produced from the mated females. In contrast, 5 and 10 mg/mL WCE treatment didn’t have effect on the duration time of mating latency and the number of progenies in Drosophila compared to the untreated controls. In conclusion, an ethanolic extract of C. rotundus exhibits potential of sexual behaviors and reproductive fitness in Drosophila. Our finding might contribute to the potential pharmacological effect of C. rotundus ethanol extract as aphrodisiac agent.


Keyword:

Cyperus rotundus L., Aphrodisiac, Drosophila melanogaster, Reproductive fitness




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