[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.04.20.039Pharm Sci Asia 2021; 48(4), 367-374
 

Performance of the GRACE 2.0 and EPICOR risk scores for predicting 1-year postdischarge mortality in Vietnamese patients with acute coronary syndrome

Thang Nguyen1*, Phuong Thi Bich Vo2, Hieu Thi Minh Huynh2, An Viet Tran3, Ca Ho Mai Tran1, Mai Tuyet Vi1, Thu Tran Anh Truong1, Thao Huong Nguyen2, Katja Taxis4

1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam
2 Department of Clinical Pharmacy, School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
3 Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam
4 Unit of Pharmacology Therapy, Epide- miology & Economics, Groningen Re- search Institute of Pharmacy, University of Groningen, Groningen, The Netherlands


We aimed to determine the performance of the Global Registry of Acute Coronary Events (GRACE) risk score version 2.0, and the long-term follow up of antithrombotic management patterns in acute coronary syndrome patients (EPICOR) risk score for predicting 1-year postdischarge mortality in patients with acute coronary syndrome (ACS) in Vietnam. A prospective cohort study was conducted on 455 patients who were discharged with an ACS diagnosis from two hospitals in Can Tho, and one in Ho Chi Minh City. Online simplified EPICOR and GRACE 2.0 calculators were used to assess the expected risk of death. We compared the performance of predicting 1-year mortality between GRACE 2.0 and EPICOR risk scores by using the Hosmer-Lemeshow test, the area under the curve (AUC), and the De-Long test. The proportions of low-risk group, moderate-risk group, and high-risk group for GRACE were 31%, 42%, and 27%, respectively. Actual mortality rates for the low, medium and high-risk groups were 3.6%, 9.4%, and 19.4%. The proportions of low-risk and high-risk patients for EPICOR were 92.0% and 8.0%, respectively. The actual mortality rate of the high-risk group was 31.4%, and of the low-risk group 8.6%. Hosmer-Lemeshow test results of the GRACE 2.0 and EPICOR were 0.337 and 0.001, respectively. The AUC results of the GRACE 2.0 and EPICOR were 0.703 and 0.752 respectively, and the De-Long test with p = 0.0532. In conclusion, the GRACE 2.0 was better than EPICOR in predicting 1-year postdischarge mortality in Vietnamese patients with ACS.


Keyword:

GRACE 2.0, EPICOR, mortality risk scores, acute coronary syndrome, Vietnamese.




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