[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.04.20.061Pharm Sci Asia 2021; 48(4), 339-345
 

Co-administration of hydroalcoholic Viola odoratas extract and streptozotocin on histopathological and biochemical changes in rat kidney

Rouhollah Gazor1, Atieh Ashouri2, Monireh Aghajany-nasab3, Fatemeh Yousefbeyk4, Behrooz Khakpour Taleghani5, Fahimeh Mohammadghasemi1*

1 Cellular & Molecular Research Center, Department of Anatomy, School of Medicine, Guilan University of Medical Sciences, Rasht-Iran
2 Student Research Center, Department of Anatomy, School of Medicine, Guilan University of Medical Sciences, Rasht-Iran
3 Cellular & Molecular Research Center, Department of Biochemistry, School of Medicine, Guilan University of Medical Sciences, Rasht-Iran
4 Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht-Iran
5 Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht-Iran


This study aimed to evaluate the effect of hydroalcoholic Viola odorata extract (VOE) on kidney tissue in a diabetic rat model induced by streptozotocin (STZ). Male Wistar rats were randomly divided into five groups: 1. Vehicle controls, 2. STZ, 3. STZ+ 100 mg/kg (VOE), 4. STZ+ 200mg/kg (VOE) 5. STZ+ 400 mg/kg (VOE). At the end of the experiment serum and urinary levels of urea, creatinine, albumin, serum glucose, and MDA levels were measured. Tuft glomerular and renal corpuscles area, epithelial height in proximal and distal convoluted tubules (PCT and DCT) were quantitatively measured in histologic slides. VOE in doses of 100, 200, and 400 mg/kg significantly reduced the serum glucose level. VOE in dose of 200 mg/kg reduced urine albumin, creatinine, and urea in comparison with STZ treated group (P<0.001). VOE in a dose of 400 mg/kg also reduced urine albumin (P<0.01). There were no significant statistical differences in serums' kidney markers between the STZ and VOE groups. 100 mg/kg and 200 mg/kg of VOE reduced serum MDA level compared to the STZ group. Treatment with various doses of VOE effectively reduced both the tuft glomerular and renal corpuscles area. Epithelial height in PCT and DCT reduced in STZ treated group compared to controls. 200 mg/kg VOE increased them significantly (P<0.001).The results showed that VOE has hypoglycemic properties. VOE may protect renal function induced by STZ, especially in a dose of 200 mg/kg and through reduction of oxidative stress.


Keyword:

Viola, Diabetes, Kidney, Oxidative stress




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