[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.04.20.069Pharm Sci Asia 2021; 48(4), 375-380
 

Pharmacokinetics and pharmacodynamics of low dose 300 mg once daily oral linezolid for treatment of tuberculosis

Sutep Jaruratanasirikul1*, Jetsada Piwluang2, Somchai Sriwiriyajan2,3, Monchana Nawakitrangsan1, Maseetoh Samaeng1, Nuntiya Theerapakanunt1

1 Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand
2 Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla, Thailand
3 Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla, Thailand


Tuberculosis (TB), an infectious disease caused by the Mycobacterium tuberculosis bacteria, continues to be an immense global public health problem and still remains a leading cause of death among infectious diseases, especially in developing countries. In the last few decades, the incidences of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB have been increasing and have become a significant public health threat in many countries. Linezolid, an oxazolidinone antimicrobial agent, has been shown to be effective against M. tuberculosis, including MDR- and XDR-TB. However, a daily regimen of 1200 mg or even 600 mg of linezolid for treatment of MDR- and XDR-TB has potential toxicities. A daily 300 mg dose of linezolid would be an effective treatment against MDR- and XDR-TB with fewer adverse effects. The objective of this study was to determine the pharmacokinetics (PK) of a 300 mg daily dose of oral linezolid for achieving the pharmacodynamic (PD) targets. Thirty healthy subjects received 300 mg oral linezolid once daily and PK studies were carried out on day 5 after the beginning of drug administration. The mean value of AUC0-24 of this agent was calculated for the achievement of PD targets. The mean values of Vd, CL and AUC0-24 were 29.08 ± 10.75 L, 3.69 ± 1.58 L/h and 94.38 ± 35.12 mg.h/L, respectively. The AUC0-24/MIC ratio for a MIC of 0.9 and 0.75 mg/L were approximately 100 and 119, respectively. In conclusion, 300 mg of linezolid daily is an alternative antibiotic option in patients with intolerance to the side effects of the standard dosage regimens.


Keyword:

Pharmacokinetics, Pharmacodynamics, Linezolid, Tuberculosis, Multidrug- resistance




Download full paper (PDF File size: 958.12 KB.)





Vol.48
No.6
November-December 2021

See other volume

 


Vol.48
No.5
September - October 2021

See other volume

 


Vol.48
No.4
July - August 2021

See other volume

 


Vol.48
No.3
May - June 2021

See other volume

 


Vol.48
No.2
March - April 2021

See other volume

 


Vol.48
No.1
January - February 2021

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.