[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2021.06.21.047Pharm Sci Asia 2021; 48(6), 506-515

The antidiabetic and protective effects of the methanolic leaf extract of A. borneensis in alloxan-induced diabetic rats

Amal Hazirah Matusin1, May Poh Yik Goh1, Norhayati Ahmad1,2*

1 Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, Brunei Darussalam
2 Institute for Biodiversity and Environmental Research, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, Brunei Darussalam

Aidia borneensis or locally known as “sambah bagangan” is consumed as herbal tea in Brunei Darussalam and has been claimed to provide several health benefits. Our study was conducted to determine antidiabetic and protective effects of the methanolic extracts of A. borneensis followed by a histopathological evaluation of the pancreatic islets regeneration in response to the treatments. The study was conducted on male Wistar rats, aged 8-10 weeks where diabetes was induced via a single intraperitoneal injection of alloxan at 120 mg/kg body weight (b.w.). The rats were then treated with a low dose (LD) of 250 mg/kg b.w. or a high dose (HD) of 500 mg/kg b.w. of the A. borneensis extract pre- or post-alloxan administration followed by evaluation of blood glucose levels and histological evaluation of the pancreatic islets over a 12-week experimental period. The intraperitoneal glucose tolerance test for the treated animals was also carried out. Our results report a significant reduction in the blood glucose concentration and increase in ratio of islets to tissue size observed in diabetic rats from both low dose and high dose treated groups compared to the control animals (p<0.05). Improvement of islet morphology was evident in the treated animals. Similar patterns of increased islet to tissue size ratios were also observed in the protective group which received pre-treatment of the extracts prior to diabetes induction. Overall, the present study shows that methanolic extract of the A. borneensis leaf exhibited apparent antidiabetic and protective effects on alloxan-induced diabetic rats.


Aidia borneensis, Pancreas, Islet regeneration, Beta cells, Diabetes

Download full paper (PDF File size: 2,449.55 KB.)

November-December 2021

See other volume


September - October 2021

See other volume


July - August 2021

See other volume


May - June 2021

See other volume


March - April 2021

See other volume


January - February 2021

See other volume


Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
All Volumes & Issues
Submit Online
Contact us
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register

Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.