[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2021.05.20.089Pharm Sci Asia 2021; 48(5), 420-424

The occurrence of multi-drug-resistant (MDR) Salmonella typhi in Southern Benue, Nigeria

Peter Adikwu1*, Ebele Uchenna Umeh2, Innocent Okonkwo Ogbonna2, Charles Chidozie Iheukwumere2, Godwin Attah Obande3, Oyiwona Emmanuel Godwin4, Adejor Johnson4

1 Biological Science Department, Benue State University, Makurdi, Nigeria
2 Department of Microbiology, Federal University of Agriculture, Makurdi, Benue State, Nigeria
3 Department of Microbiology, Federal University, Lafia, Nassarawa State, Nigeria
4 Department of Science Laboratory Technology, Benue State Polytechnic, Ugbokolo, Nigeria

Typhoid fever, whose causal agent is Salmonella typhi has high endemicity in developing countries. This study investigated the distribution of multidrug resistant S. typhi in Southern Benue, Nigeria. Stool samples were obtained from 583 (57.0%) male and 439 (43.0%) female patients presumptively diagnosed with typhoid fever in government hospitals within the study area. Isolation and identification of S. typhi followed standard cultural and biochemical procedures using a range of selective culture media. The Salmonella typhi isolates were subjected to antibiotic susceptibility test using the standard disc diffusion method (Kirby-Bauer), and results were interpreted using the criteria of the Clinical Laboratory Standards Institute. Chi-square and analysis of variance (ANOVA) were used to determine associations amongst variables were used to determine associations between variables at 95% confidence level. Isolates from Ohimini (57.1%, n=12) had the highest rate of multidrug-resistant strains, while Agatu (13.7%; n=7) had the least. Age groups >60, ?10 and 21-30 exhibited high MDR rates of 50.0%, 32.8% and 30.8% respectively. Isolates from female patients, (33.3%) had higher MDR rate than their male (23.1%) counterparts. The results showed a statistically significant difference in the prevalence of MDR S. typhi in the various locations sampled. The rate of MDR S. typhi isolates demonstrated in this study is remarkable and of great concern.


Occurrence, Salmonella typhi, Multi-drug, Resistance, Typhoid

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