[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2021.02.19.125Pharm Sci Asia 2021; 48(2), 175-184

α-Glucosidase, α-amylase inhibitory effects and anti-oxidative activity of Tetracera loureiri (Finet & Gagnep.) Pierre ex Craib leaf extracts

Siriporn Kittiwisut1*, Surattana Amnuoypol1, Pathamaporn Pathompak2, Sukanya Setharaksa2

1 Medical Chemistry and Natural Products Research Unit, Division of Pharmaceutical Science, Faculty of Pharmacy, Thammasat University (Rangsit Campus), Pathumthani, Thailand
2 Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathumthani, Thailand

Tetracera loureiri (Finet & Gagnep.) Pierre ex Craib leaf extracts were evaluated the inhibitory effect of diabetes mellitus (DM)-related enzymes including ?-glucosidase and ?-amylase. The high polarity extracts, methanol-(TTL1) and aqueous-methanol-(TTL4) extracts, displayed higher potency than the nonpolar and low polarity extracts (hexane- and dichloromethane-extracts). Both extracts also expressed enzyme inhibitory activity stronger than those of positive control, acarbose. Additionally, they also exhibited good antioxidative effects conducted from DPPH radical scavenging activity and ferric reducing power. The antioxidant effects of both polar extracts were comparable to those of positive controls, quercetin and Trolox. These antioxidative properties have been expected to synergize antidiabetic activities by preventing DM complications. Therefore, the prominent bioactivities of the polar extracts, TTL1 and TTL4, are attractive to further isolate the active components for antidiabetic agent development.


Tetracera loureiri; ?-Glucosidase inhibition; ?-Amylase inhibition; Antioxidative activity

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