[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2021.01.19.120Pharm Sci Asia 2021; 48(1), 90-98
 

Characterization and antihypertensive activity of ginger extracteel bone oil SNEDDS (self-nanoemulsifying drug delivery system)

Fea Prihapsara1*, Imas Ifrian Wijayanti2, Agung Budiharjo2,3, Artini Pangastuti2,3, Anif Nur Artanti1

1 Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sebelas Maret-University, Central Java, Indonesia
2 Bioscience Graduate Program, Sebelas Maret -University, Central Java, Indonesia
3 Department of Biology, Faculty of Mathematics and Natural Sciences, Sebelas Maret -University, Central Java,Indonesia


This research aimed to determine the characterization of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Zingiber officinale extract with eel (Anguilla spp.) bone oil and activity on systolic and diastolic blood pressure of Wistar rats with dexamethasone-induced hypertension. Hypertension was induced by giving rats subcutaneous dexamethasone injections (30 μg/kg/day) for 14 days. In prevention group, rats received oral 200 mg/kg BW of crude ginger extract (GE), 200 and 300 mg/kg BW SNEDDS ginger extract (200 SGE and 300 SGE), and 40 mg/kg BW captopril from 4 days before and during treatment period (days 1-18). In curative treatment group, SNEDDS ginger extract was administered orally from days 8-14. The results, using a UV spectrophotometer showed the transmittance of SNEDDS was 92.16%; the optimal emulsification time was 10.01 seconds in artificial gastric fluid (AGF), 10.15 seconds in distilled water, and 9.44 seconds in double-distilled water, with a measured particle size of 13.10 nm, polydisperse index 0.134 and zeta potential of -14.04 mV. The antihypertensive activity analyzed by two-way ANOVA (p<0.05) showed that 200 SGE and 300 SGE have effectiveness for preventing symptoms of hypertension. In curative group showed significant different systolic blood pressure between SNEDDS ginger extract and crude ginger extract. This indicated that the tested SNEDDS ginger extract was effective for treating symptoms of hypertension.


Keyword:

Eel bone oil; diastolic; ginger extract; self-nano emulsifying drug delivery system (SNEDDS); systolic




Download full paper (PDF File size: 874.19 KB.)





Vol.48
No.6
November-December 2021

See other volume

 


Vol.48
No.5
September - October 2021

See other volume

 


Vol.48
No.4
July - August 2021

See other volume

 


Vol.48
No.3
May - June 2021

See other volume

 


Vol.48
No.2
March - April 2021

See other volume

 


Vol.48
No.1
January - February 2021

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2022
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.