[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2021.02.19.094Pharm Sci Asia 2021; 48(2), 122-138

Preparation and physicochemical evaluation of hydrogel containing quercetin phytosomes

Thi-Thu-Giang Vu1*, Hong-Trang Nguyen2, Thi-Hai-Yen Tran1, Bao-Tung Pham1, Thi-Minh-Hue Pham1

1 Department of Pharmaceutics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong Street, Hoan Kiem District, Hanoi, Vietnam
2 Hue University of Medicine and Pharmacy, 6 Ngo Quyen Street, Hue, Vietnam

The objective of this study was to prepare and evaluate some physiochemical properties of the hydrogel containing quercetin phytosomes. Quercetin phytosome suspension was prepared by anti-solvent precipitation method followed by evaluation of the drug entrapment efficiency, mean particle size, and particle distribution index (PDI). The particle size of quercetin phytosomes was in the narrow range of 400 - 500 nm with PDI < 0.4, the absolute value of zeta potential was higher than 30 mV. Analysis of Fourier-Transform Infrared Spectroscopy and proton nuclear magnetic resonance spectroscopy proved the presence of physical and chemical interactions between quercetin and phospholipid. The quercetin–hydrogenated soybean phosphatidylcholine complex was formed by hydrogen and ion-dipole bonding between the -OH group of the phenyl rings of quercetin and the -P=O, -N(CH3)3 group of the phospholipids. In scanning electron microscope (SEM) images, the quercetin phospholipid complex was found to be irregular and disc-shaped with a rough surface. Later, quercetin phytosomes were incorporated into the hydrogel system using Carbopol 934 or sodium carboxy-methyl cellulose. The optimal formula of quercetin phytosome hydrogel containing 0.1 % active ingredient had the particle size in the range of 400 - 500 nm with PDI < 0.4 as they were in the phytosome suspension. The release rate and deposition of quercetin from the phytosome quercetin hydrogel were increased significantly by more than 3 times and 6 times, respectively in comparison with the conventional hydrogel.


Phytosomes; Quercetin; Anti-solvent Precipitation method; Hydrogel; In vitro release.

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