| DOI: 10.29090/psa.2021.02.20.023 | Pharm Sci Asia 2021; 48(2), 139-146 |
Comparison eugenol and oleic acid as a plasticizer on characteristic of dextromethorphan hydrobromide film by solvent casting methodNining Nining*, Rahmah Elfiyani, Elvira Wulandari
- Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia
Dextromethorphan hydrobromide (DH) is a cough suppressing drug as strongly as codeine but lasts longer. Orally dissolving film (ODF) from combination pomelo skin pectin and chitosan is strong but stiff. Formulation of the film added oleic acid and eugenol as a plasticizer was to improve tensile strength and elongation. This study aimed to compare the influences of plasticizer usage against the characteristics of DH film. Pectin of pomelo skin was extracted using the reflux method. Organoleptic properties, identification test, ash content, moisture content, equivalent weight, and methoxyl content was evaluated characteristic of pectin. DH film was produced using oleic acid (DHF-oleic acid) and eugenol (DHF-eugenol) on a concentration of 2%, 4%, and 6%. Organoleptic properties, uniformity weight,thickness, tensile strength, percent elongation, pH, disintegration time, determination level, and uniformity level was evaluated of film characteristic. The result of this study indicated that pectin characteristic conforms to requirements of high methoxyl form i.e., 7.43%. Evaluation results for both films showed organoleptic properties, uniformity weight, thickness, pH, and disintegration time have a similarity. Whereas tensile strength and percent elongation properties, DHF-eugenol has significantly different than DHF-oleic acid. In conclusion, eugenol as a plasticizer produced better film characteristics than oleic acid at all various concentrations on DH film.
Keyword:
Eugenol; Oleic acid; Plasticizer; Dextromethorphan hydrobromide; Film
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