[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2023.04.23.116Pharm Sci Asia 2023; 50(4), 273-280

Exploring the potential use of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) peels as sources of cosmaceutical sunscreen agent for their antioxidant and photoprotective properties

Nadia Zeghad1*, Ejaz Ahmed2, Muhammad Zakryya Khan3, Abdelmalik Belkhiri4

1 Laboratory of pharmacology and toxicology, veterinary institute, Constantine 1 University, Algeria
2 Department of Botany, Faculty of Sciences, PMAS-Arid Agriculture University Rawalpindi, Pakistan
3 Department of Biotechnology, Faculty of Basic and Applied Sciences, International Islamic University Islamabad, Pakistan
4 Laboratory of Pharmacognosy, Faculty of Medicine, University Constantine 3, Algeria

Nowadays, consumer’s demand for natural sources-derived sunscreen products, to get photoprotection from harmful ultraviolet radiations is forcing cosmetic industry to develop such breakthrough formulations by incorporating antioxidants as active phytochemical ingredients. Plant extracts are currently being focused for the purpose, but bio-wastes including fruit peels remain yet unexplored and consequently, underutilized. The present study is aimed to evaluate the photoprotective and antioxidant potential of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) fruit peels extracts and to valorize their potential use as sources in cosmeceutical sunscreen agents. The selected extracts were estimated for antioxidant activity by DPPH, ABTS, FRAP, CUPRAC and GOR methods and their antioxidant properties were correlated to reference standards (BHT and BHA). The sun protection factor (SPF) was used to assess their photoprotective effect (SPF) in vitro. It was found that hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract possessed highest antioxidant activities significantly (p˂0.0001) in all the methods compared to peel fruit prickly pear (Opuntia ficus indica L.) extract, possessing rich source of antioxidants. Hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract, also presented the highest phenolic content. It was found that antioxidant activity was due to phenolic compounds containing flavonoids and confer photoprotection. The highest SPF was also related to hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract with highest levels of protection against ultraviolet light with sun protection values ranging at 44.402±0.438. It is rational to apply these active compounds from waste to sunscreens, in order to increase UV protection.


Punica granatum L., Opuntia ficus indica L., Peel fruit extract, Antioxidant activity, Sun Protection Factor (SPF)

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