[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2023.04.23.616Pharm Sci Asia 2023; 50(4), 347-360

Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation

Tejas Suresh Telange, Shivani Santosh Pawar, Akash Jayendra Amkar, Bhushan Rajendra Rane*, Ashish Suresh Jain

- Shri D. D. Vispute College of Pharmacy and Research Center Panvel, Maharshtra, India

Acyclovir (ACV) is an antiviral drug that is primarily used to treat herpes zoster virus (HSV) infections. HSV infections in deeper regions of the skin, i.e., nerve junctions, and appeared as a red spot on the upper part of the skin. The objective of the research is to formulate and evaluate an emulgel loaded with ACV microemulsion (ME) in order to treat herpes infections and to get effects from the deeper region of the skin. MEs were prepared by high-pressure homogenization, and then microemulgels were prepared by the dispersion method. Microemulgel characteristics are being determined, and an in vitro diffusion study was performed. In this study, we have developed and evaluated an ACV-loaded microemulgel using Carbopol 940 as the gelling agent. The characteristics and stability of ACV-loaded microemulgels were studied, and in vitro drug diffusion of the optimized microemulgel, i.e., MEG3, was found to be 95±2.4% with a sustained effect for 8 hours. Observation shows that the optimized microemulgel has a smaller globule size, and hence it may move to the deeper regions of the skin. Stability studies did not show any significant change; hence, it is apparent that the drug substance or product will remain within the acceptance criteria during shelf life. It was concluded that the ACV-loaded microemulgel was prepared successfully for transdermal delivery.


Microemulgel, Acyclovir, Transdermal, Surfactant, In vitro diffusion

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