[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2023.04.23.618Pharm Sci Asia 2023; 50(4), 361-370

Pharmaceutical cocrystal-a deft technique for solubility enhancement

Sayani Bhattacharyya*, Archana Manjunath

- Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bengaluru, India

Solubility enhancement of active pharmaceutical ingredients is a challenging field in the pharmaceutical industry. Several methods and excipients are employed in the solubility improvement process of poorly soluble drugs. Crystal engineering is one of the novel strategies to alter the physicochemical properties of the molecule without causing significant changes in its structural integrity. Cocrystals are single-phase or homogeneous crystalline structures composed of two or more compounds bound noncovalently with the active pharmaceutical ingredient in a definite stoichiometric ratio. The cocrystallization technique is effective not only in improving the problems associated with solubility, and bioavailability, in addition, it enhances permeability, stability, hygroscopicity, flowability, and processability of the materials. This review represents the concept, characterization, and application of cocrystals in a systematic way. The review focuses on the requisite and mechanism of cocrystal formation, different preparation methods of cocrystals, and stages of screening. The growing interest in this technique has led the regulatory bodies to implement the guidelines, hence, a brief on regulatory perspectives is discussed here. The cocrystallization method establishes its potential in the pharmaceutical field through an increasing number of patents and market approvals.


Cocrystal, Co-former, Cocrystallization method, Solubility enhancement, Cocrystal Evaluation

Download full paper (PDF File size: 525.53 KB.)

October-December 2023

See other volume


July-September 2023

See other volume


April-June 2023

See other volume


January-March 2023

See other volume


Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
All Volumes & Issues
Submit Online
Contact us
Faculty of Pharmacy Mahidol University
Mahidol University

Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.