[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2023.03.22.187Pharm Sci Asia 2023; 50(3), 238-246
 

Evaluation of acute and subacute toxicity of Abhrasindoora: As a mercury-based traditional herbo-bio-mineral metallic formulation

Rakesh Bramhankar1*, Abhaya Kumar Mishra2*, Snigdha Das3, Nisha Munishwar4

1 Department of Rasashastra & Bhaishajya Kalpana, Parul Institute of Ayurved and Research, Parul University, Vadodara, Gujarat, India
2 Department of Rasashastra & Bhaishajya Kalpana, Sri Sri College of Ayurvedic Science and Research Hospital, Sri Sri University, Bidyadharapur, Arilo, Cuttack, Odisha, India
3 Department of Pharmacology, Parul Institute of Pharmacy & Research, Parul University, Vadodara, Gujarat, India
4 Department of Kayachikitsa, Parul Institute of Ayurveda & Research, Parul University, Vadodara, Gujarat, India


Herbo-bio-mineral metallic preparations such as Abhrasindoora offer advantages over plant drugs under their stability over a period, lower dosage, and contain minerals and metals as an integral part of the formulations. The use of metals in medicine is often associated with toxicity. Present study was conducted to explore the acute and sub-acute toxicity study of Abhrasindoora in Wistar albino rats. Information related to possible health hazards, the estimate of no-observe-adverse-effect-level (NOAEL), hematology, and biochemical and histopathology parameters were studied. For the acute toxicity study rats were divided into two groups: Group I (Test group: 300 mg/kg) and Group II (Confirmatory group: 2,000 mg/kg) as per OECD 423 guidelines and for subacute toxicity study, rats were divided into four groups as Group I (water as the vehicle), Group II (600 mg/kg), Group III (800 mg/kg) and Group IV (1,000 mg/kg) as per OECD 407 guidelines. Clinical signs (daily); body weight and feed consumption (weekly) were taken. Blood samples were collected from the retro-orbital sinus before the necropsy (29th day). For statistical analysis, one-way ANOVA and Dunnetts test were used. In comparison to the control group, no mortality or adverse effects were observed. No significant variations were observed in hematological and biochemical parameters. In target organs, no significant changes were observed in both acute and sub-acute toxicity studies. No deaths or any signs of toxicity were observed after oral administration in the acute toxicity study up to the dose of 2,000 mg/kg and in the sub-acute toxicity study up to the dose of 1,000 mg/kg.


Keyword:

Abhrasindoora, Herbo-Bio-Mineral Metallic formulation, Acute toxicity, Sub-acute toxicity




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Vol.50
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July-September 2023

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January-March 2023

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