[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2023.01.22.160Pharm Sci Asia 2023; 50(1), 34-40

Effect of zonisamide and Nigella sativa on blood-brain barrier permeability and neurological severity in traumatic brain injury-induced mice

Sandeep Kumar, Govind Singh*

- Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

Traumatic brain injury (TBI) is a primary public health issue that has resulted in millions of deaths and disabilities worldwide. There are a variety of drugs available to help with TBI-related consequences, but they do not prevent further impairment. As a result, new therapeutic drugs that protect against neuronal damage caused by trauma and its implications, particularly secondary injury, are needed. Swiss albino mice (25-30 g) of either sex were utilized in the investigation. The weight-drop method was used to cause TBI. Following the treatment of zonisamide (100 mg/kg) and Nigella sativa (NS) (300 mg/kg) separately and in combination, blood-brain permeability was assayed. The albumin content in CSF and the level of Evan's blue in the brain diminution significantly in drug-treated groups. The neurological severity score in the co-administered group was found similar to that of the control group (no significant difference compared to the control group) on days 7 and 21. The results affirmed the potential of both drugs in preventing TBI-induced blood-brain barrier damage and reducing neurological severity.


Blood-brain barrier, Nigella sativa, Neurological severity score, Traumatic brain injury, Weight drop model, Zonisamide

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