| DOI: 10.29090/psa.2023.04.23.618 | Pharm Sci Asia 2023; 50(4), 361-370 |
Pharmaceutical cocrystal-a deft technique for solubility enhancementSayani Bhattacharyya*, Archana Manjunath
- Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bengaluru, India
Solubility enhancement of active pharmaceutical ingredients is a challenging field in the pharmaceutical industry. Several methods and excipients are employed in the solubility improvement process of poorly soluble drugs. Crystal engineering is one of the novel strategies to alter the physicochemical properties of the molecule without causing significant changes in its structural integrity. Cocrystals are single-phase or homogeneous crystalline structures composed of two or more compounds bound noncovalently with the active pharmaceutical ingredient in a definite stoichiometric ratio. The cocrystallization technique is effective not only in improving the problems associated with solubility, and bioavailability, in addition, it enhances permeability, stability, hygroscopicity, flowability, and processability of the materials. This review represents the concept, characterization, and application of cocrystals in a systematic way. The review focuses on the requisite and mechanism of cocrystal formation, different preparation methods of cocrystals, and stages of screening. The growing interest in this technique has led the regulatory bodies to implement the guidelines, hence, a brief on regulatory perspectives is discussed here. The cocrystallization method establishes its potential in the pharmaceutical field through an increasing number of patents and market approvals.
Keyword:
Cocrystal, Co-former, Cocrystallization method, Solubility enhancement, Cocrystal Evaluation
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