| DOI: 10.29090/psa.2023.03.23.105 | Pharm Sci Asia 2023; 50(3), 257-265 |
Beneficial effects of red rice bran extract on brown adipose tissue whitening, inflammation, and oxidative stress in mice with obesity induced by a high-fat dietNattanida Jantarach1, Wirinya Mueangchang1, Jatuporn Prathumtet2, Narongsuk Munkong3*
1 Applied Thai Traditional Medicine Program, School of Public Health, University of Phayao, Phayao, Thailand
2 Division of Thai Traditional Medicine, Faculty of Natural Resources, Rajamangala University of Technology Isan, Sakon Nakhon Campus, Sakon Nakhon, Thailand
3 Department of Pathology, School of Medicine, University of Phayao, Phayao, Thailand
Red rice bran extract (RRBE) has been demonstrated to have anti-lipid accumulation, antioxidant, and anti-inflammatory effects on the livers of obese animals and/or in macrophages. However, the molecular mechanisms driving these effects have not yet been investigated in brown adipose tissue (BAT). Thus, the present study aimed to investigate the beneficial effects of RRBE on BAT in mice with obesity induced by a high-fat diet (HFD). Six weeks after induction of obesity, the obese mice were fed continuously with HFD, with or without RRBE treatment for 6 weeks. Body weight and food intake were recorded weekly. At the end of the feeding experiment, BAT was collected for determination of expressions of genes associated with liporegulation, inflammation, and oxidative stress, as well as histological examination. Compared with untreated obese mice, RRBE-treated mice had reductions in body weight, food efficiency ratio, and white-like adipocytes in BAT, accompanied by down-regulated expres-sion of nuclear receptor subfamily 1 group H member 3 (NR1H3). Moreover, RRBE decreased the levels of nitric oxide (NO), reactive oxygen species (ROS), and malondialdehyde (MDA) in BAT, which were associated with modulated expressions of target genes for nuclear factor-kappa B and nuclear factor erythroid 2-related factor 2. RRBE produced beneficial effects against HFD-induced abnormalities in BAT by mitigating whitening, inflammation, and oxidative stress.
Keyword:
Red rice bran, Brown adipose tissue, Obesity
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