[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2022.03.22.029Pharm Sci Asia 2022; 49(3), 265-272
 

Phytochemical composition of Blumea lacera leaf and its inhibitory effects on the activity of enzymes related to metabolic diseases

Mohammad Rowshanul Habib1*, Yasuhiro Igarashi2, Mohammad Ahasanur Rabbi3

1 Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
2 Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, Japan
3 BCSIR Laboratories Rajshahi, Bangladesh Council of Scientific and Industrial Research, Rajshahi, Bangladesh


Blumea lacera (Bum. f.) DC is an important medicinal plant of Bangladesh having several ethnomedicinal values. To give the scientific basis of ethnomedicinal uses, the present study analyzed phytochemical composition of methanol extract of B. lacera leaves (designated as MBLE) and evaluated its inhibitory effects on pancreatic lipase, α-amylase, xanthine oxidase (XO) and angiotensin I-converting enzyme (ACE). Different in vitro methods were used to perform enzyme inhibition assays for MBLE and its phytochemical profile was analyzed by GC-MS. In case of all the enzyme inhibition assays, the percentage of inhibition by MBLE was increased with increasing in concentrations. Among these enzymes, MBLE showed strong activity (IC50:13.34±1.05 μg/mL) against ACE as compared with captopril (IC50:8.09±0.74 μg/mL) used as standard reference whereas it exhibited moderate activity against other enzymes. The IC50 values of MBLE were found to be 9.87±0.25, 40.17±2.32 and 93.88±5.21 μg/mL for pancreatic lipase, α-amylase and XO, respectively. In addition, some compounds identified in MBLE by GCMS, were also consistence with these enzyme inhibitory activities. Thus, this study demonstrates the enzyme inhibitory potentials of B. lacera leaves for the first time and it might be a potential tool for the treatment of metabolic diseases.


Keyword:

Phytochemical composition, Blumea lacera, Leaves, Inhibition, Enzyme, Metabolic diseases




Download full paper (PDF File size: 1,420.36 KB.)





Vol.49
No.3
May-June 2022

See other volume

 


Vol.49
No.2
March-April 2022

See other volume

 


Vol.49
No.1
January-February 2022

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2022
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.