[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2022.03.21.184Pharm Sci Asia 2022; 49(3), 223-229

Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in Vietnam

Nhung Thi Cam Tran1, Khanh Hoang Pham2*, Thang Nguyen2, Dao Huynh Tran3, Hung Xuan Tong4, Chung Van Nguyen5

1 Hoan My Cuu Long Hospital, Can Tho City, Vietnam
2 Can Tho University of Medicine Pharmacy, Can Tho City, Vietnam
3 Can Tho Central General Hospital, Can Tho City, Vietnam
4 108 Military Central Hospital, Hanoi, Vietnam
5 University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam

We aimed to compare intraoperative sedation and postoperative analgesic effects of brachial plexus block using bupivacaine-dexmedetomidine mixture (BD) versus bupivacaine alone (B) in upper extremity bone surgeries. We conducted a randomized comparative study at Can Tho City, Vietnam. We recruited patients aged 15 to 75 years, ASA (American Society of Anesthesiology) I-III grade, indicating bone surgeries of arm or forearm with supraclavicular brachial plexus block by ultrasound guidance. One hundred eight included patients were randomly divided into two groups: the BD group (54 patients) received a 30 ml mixture of 0.25% bupivacaine and 100 mcg dexmedetomidine, and the B group (54 patients) received 30 ml of 0.25% bupivacaine. The BD group had a sedative OAA/S score (Observer Assessment of Alertness/Sedation Scale) of level 4, accounting for 87% more than group B 37%, and an OAA/S score of level 3 in the BD group with 5 cases (9.3%) compared with 9 cases (16.7%) in group B, statistically significant difference with p<0.05. The onset and duration of sedative time in group BD was 9.8±3.5 and 92.7±34.1 minutes. The mean of postoperative analgesic time was 970.5±309.5 minutes in group BD statistically significantly longer than group B’s with 552.7±231.2 minutes (p<0.001). In conclusion, a mixture of bupivacaine-dexmedetomidine in brachial plexus block for arm and forearm surgical fractures had greater sedative and postoperative analgesic effects than that of bupivacaine alone.


Brachial plexus block, Bupivacaine, Dexmedetomidine, Intraoperative sedation, Postoperative pain relief, Ultrasound guidance

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