[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2020.04.019.0098Pharm Sci Asia 2020; 47(4), 347-356
 

Physical stability of different chitosan salts in matrix tablet formulations

Kampanart Huanbutta1,2, Tanikan Sangnim1,2, Kamonrak Cheewatanakornkool2,4, Lalinthip Sutthapitaksakul2,3, Kasitpong Thanawuth2,3, Pornsak Sriamornsak2,3,5*

1 Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand
2 Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
4 Pharma Nueva Co., Ltd., Chatuchak, Bangkok, Thailand
5 Academy of Science, Royal Society of Thailand, Bangkok, Thailand


This study aimed to evaluate the physical stability of chitosan (CS) and its salt forms, including chitosan glycolate (CGY) and chitosan lactate (CL), as diluent in matrix tablets for the modified-release dosage form. Caffeine, theophylline, and theobromine were selected as model drugs in this study because of its similarity in chemical structure but difference in solubility. In vitro drug release, hardness, and tablet weight of the drug-loaded matrix tablets made of CS or CS salts were assessed after preparation and 6 months of storage for physical stability monitoring. After 6 months under the accelerated storage condition, the hardness of the CS and CS salt matrix tablets without drug increased, whereas the hardness of the drug-loaded matrix tablets decreased. After 6 months, the weight gain of the CS matrix tablets was approximately 2.63% to 4.97%. In addition, storage of the CGY and CL matrix tablets for 6 months significantly caused rapid drug release. Results show that the application of CS as tablet excipient should be closely monitored and evaluated because of its low stability and hygroscopic property.


Keyword:

Chitosan, Chitosan salts, Physical stability, Matrix tablet




Download full paper (PDF File size: 2,901.27 KB.)





Vol.47
No.4
October - December 2020

See other volume

 


Vol.47
No.3
July - September 2020

See other volume

 


Vol.47
No.2
April - June 2020

See other volume

 


Vol.47
No.1
January - March 2020

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND