[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2020.03.019.0076Pharm Sci Asia ; 47(3), 221-225
 

The role of corticosteroid for the treatment of Coronavirus Disease-2019 (COVID-19): A narrative review

Oki Nugraha Putra*, Ana Khusnul Faizah, Nani Wijayanti Dyah Nurrahman

- Department of Clinical Pharmacy, Program Study of Pharmacy, Hang Tuah University, Arief Rahman Hakim 150, Surabaya, East Java Indonesia


Acute respiratory distress syndrome (ARDS) is a most common complication in patients with severe COVID-19 with high rate of mortality. Corticosteroids have been used in the management of SARS-CoV and MERS-CoV several years ago. Data about the effectiveness of corticosteroids in the management of COVID-19 is lacking. It has been proposed that the corticosteroids have a modulatory effect by suppressing cytokine storms in severe COVID-19. The aimed of this study is to review literature that discussed the use of corticosteroids in patients with COVID-19 related ARDS. Pubmed database was used to select the article in this review with the keywords SARS-CoV-2, COVID-19, corticosteroid, pneumonia, and ARDS. Elderly and patients with underlying disease are more likely to develop severe COVID-19 and lead to ARDS. Because of the immunosuppressive activity, corticosteroid could modulate the cytokine storms in COVID-19 patients with ARDS. The use of corticosteroids may offer the benefit in COVID-19 with ARDS, by reduce the mortality rate and duration of treatment. The administration of corticosteroids should be considered in COVID-19 patients with signs of ARDS and refractory shock. The low until moderate dose and short treatment of corticosteroids are recommended to minimize the adverse effects.


Keyword:

COVID-19, ARDS, Corticosteroids, Cytokine Storms




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