[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: 10.29090/psa.2020.01.018.0045Pharm Sci Asia 2020; 47(1), 30-36

Synthesis and bioevaluation of some new N-substituted pyranophenothiazines

Thi-Thuan Nguyen1*,Hanh Dufat2,Sylvie Michel2

1 Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Ha Noi, Vietnam
2 Laboratoire de Pharmacognosie, UMR/CNRS 8638, Universit? Paris Descartes, 75006 Paris, France

Tuberculosis is a dangerous infectious disease. Because of the enlargement of multidrug-resistant strains (MDR-TB), the need of new drugs becomes more important. In the last research, 2 pyranophenothiazine series had been synthesized and bio-evaluated. Herein, eight N-substituted pyranophenothiazine derivatives from 2 series were designed, synthesized and evaluated for their antituberculosis activities. The designed compounds were prepared by alkylation reactions and all synthesized compounds were confirmed by analysis of NMR and MS spectra. Antimycobacterial activity of the synthesized compounds on Mycobacterium bovis BCG had been determined using the microdilution resazurin assay - The results showed that 4 compounds exhibited a mild inhibiting activity on the tested tuberculosis strains. These structural requirements will be taken into account for the design of further analogues in pyranophenothiazine series.


Pyranophenothiazine; Chromene; Antituberculosis; Phenothiazine derivatives

Download full paper (PDF File size: 1,424.83 KB.)

October - December 2020

See other volume


July - September 2020

See other volume


April - June 2020

See other volume


January - March 2020

See other volume


Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
All Volumes & Issues
Submit Online
Contact us
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register

Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2023
    Faculty of Pharmacy, Mahidol University, THAILAND

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.