[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 40(4),
 

Risk factors Related to Rhabdomyolysis in Thai Statin Users: A Case-control Study

P. Supsongserm, P. Boonmuang, S. Nathisuwan, N. Chaiyakunapruk, K.Tanyasaensook*

-


Previous studies on statin have revealed that increasing age, renal insufficiency, and concomitant medications were associated with rhabdomyolysis. However, there is a lack of analysis on the magnitude of such association in the Asia-Pacific region. The objectives of this study were to identify risk factors of statin-associated rhabdomyolysis in Thai patients and to evaluate the magnitude of association between the risk factors and rhabdomyolysis. The case control study was carried out at five tertiary-care hospitals in Thailand and patients’ data of 2005-2008 were collected. Data of cases with rhabdomyolysis were extracted from patient’s profiles. For each case, the researchers randomly selected ten controls for making a comparison. Data extracted included demographics, type of statins, dosage, duration, and concomitant medications. No matching of controls to cases was performed in this study and the data collectors were not blinded. Of the 220 patients, the three most commonly used were simvastatin (80.0%), atorvastatin (15.0%), and rosuvastatin (5.0%). A univariable analysis indicated that the most powerful risk factor for rhabdomyolysis was renal disease, odds ratio (OR, 24.00; 95% CI, 6.68-85.49). The number of concomitant medications was also associated with significant increased risk of rhabdomyolysis, OR 3.85 (95% CI, 1.40-10.61) and 13.23 (95% CI, 1.54-113.62) for one and two concomitant medications, respectively. In multivariable analysis, the only significant association found was between renal disease and rhabdomyolysis with a Coefficient 3.46 (95% CI, 2.21-4.71). This study reiterates that renal disease plays a key role in precipitating statin-associated rhabdomyolysis. Impaired renal function could lower elimination of statins and concomitant drugs, resulting in drug interactions and rhabdomyolysis.


Keyword:

statin, rhabdomyolysis, risk factor, drug interaction, renal disease.




Download full paper (PDF File size: 1,408.24 KB.)





Vol.40
No.4
October - December 2013

See other volume

 


Vol.40
No.3
July - September 2013

See other volume

 


Vol.40
No.2
April - June 2013

See other volume

 


Vol.40
No.1
January - March 2013

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND