[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 40(1),

Simultaneous Estimation of Metaprolol Succinate and Olmesartan Medoxomil from Capsule Dosage Form by First Order Derivative Spectroscopic Method

S. D. Jadhav*, S. M. Kumbhar, V. D. Patel, R. M. Panchal and M. S. Bhatia


Metaprolol succinate (MET) and Olmesartan medoxomil (OLM) are used in combination for treatment of hypertension. The present work deals with simple spectrophotometric method development for simultaneous estimation of MET and OLM in capsule formulation (OLSAR-M). The method employed was a first order derivative spectroscopy. For determination of sampling wavelength, 10 ?g/ml of each of MET and OLM were scanned on UV-630 double beam spectrophotometer in 200-400 nm range. The sampling wavelengths were 214 nm for OLM where MET showed zero crossing point and 231 nm for MET where OLM showed zero crossing point in first order derivative spectroscopy. For this method, linearity was observed in 10-90 ?g/ml for MET and 5-45 ?g/ml for OLM. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The method is validated as per ICH guidelines. The proposed method can be optimized further for simultaneous estimation of both drugs from biological fluids, used in pharmacokinetic and bioequivalence studies.


Derivative Spectroscopy, Metaprolol, Olmesartan, OLSAR-M, ICH.

Download full paper (PDF File size: 751.98 KB.)

October - December 2013

See other volume


July - September 2013

See other volume


April - June 2013

See other volume


January - March 2013

See other volume


Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
All Volumes & Issues
Submit Online
Contact us
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register

    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND