[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 40(3),
 

Sustained Ocular Delivery of Sparfloxacin from pH Triggered In Situ Gelling System

JS. Reddy and MG. Ahmed*

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Poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery systems prepared from polymers that exhibit reversible liquid-gel phase transitions. This may result in better ocular availability of the drug. In present work in situ gels of sparfloxacin have been developed by using HPMC and carbopol based on the concept of pH triggered gelation systems. Sol-to-gel transformation occurred in the presence of stimulated tear fluid of pH 7.4. Sparfloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. Formulations were evaluated for gelling capacity, drug content, clarity, viscosity and in vitro release. Experimental part showed that viscosity of sols was increased with increase in the concentration of polymers and the solutions shown pseudoplastic behaviour. The antimicrobial studies against Staphylococcus aureus and in vivo ocular gelation studies using suitable animal models were performed. All the results were found to be satisfactory. The formulations were therapeutically efficacious, sterile and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional drug delivery system, patient compliance, industrially oriented and economical.


Keyword:

In situ, Sparfloxacin, pH trigger, HPMC, Carbopol, In vivo studies.




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Vol.40
No.4
October - December 2013

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Vol.40
No.3
July - September 2013

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Vol.40
No.2
April - June 2013

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Vol.40
No.1
January - March 2013

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