[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 40(1),

Systematic Review of the Effectiveness of Continuous Glucose Monitoring (CGM) on Glucose Control in Type 2 Diabetes

A.M. Kyaw, N. Poolsup, and N. Suksomboon*


Forty-four percent of people with type 2 diabetes have hemoglobin A1C higher than the generally accepted target. The goal of diabetes management is to prevent diabetic complications by an as tight as possible glycemic control without the risk of severe hypoglycemia. Although UK Prospective Diabetes Study (UKPDS) group has reported that intensified diabetes management can improve glycemic control and decreases the risk of long-term microvascular complications in diabetes, high rate of hypoglycemia becomes a risk in intensive diabetic management. The fear of hypoglycemia often leads patients to forget the fatal consequences of long-term complications to avert hypoglycemic events with loss of control and cognitive dysfunction. Self-monitoring of blood glucose (SMBG) is a fundamental part of diabetes management. However, SMBG fails to detect nocturnal hypoglycemia and asymptomatic hypoglycemia. Hence, monitoring blood glucose system on a ‘continuous basis’ have been developed. This systematic review aims to support evidence regarding the effects of continuous glucose monitoring system (CGMS) on glycemic control in type 2 diabetes by collecting randomized controlled trials from MEDLINE (pubmed), Scopus, CINAHL, Web of Science and The Cochrane Controlled Trials Register and cited literature in retrieved articles. The finding shows that four studies out of five included studies presented the positive results in favor of CGMS group (HbA1c decrease; 0.6-1.16% in experimental group compared with 0.2-0.5% in SMBG group). CGMS may provide benefit over SMBG use in type 2 diabetes.


Systematic review, Continuous glucose monitoring (CGM), Type 2 diabetes, T2DM

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