| DOI: 10.29090/psa.2020.03.019.0029 | Pharm Sci Asia ; 47(3), 294-300 |
Incidence and factors associated
Post-transplantation anemia in kidney transplant patients at a tertiary-care hospital in ThailandSayamon Sukkha1, Panupong Tiansuwan1, Kunvadee Choochaeam2, Atiporn Ingsathit3,4,5, Punlop Wiwattanathum4,5, Jennis Meanwatthana1*
1 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
2 Pharmacy Division, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
3 Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
4 Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
5 Excellent Center of Organ Transplantation, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
The scarce of standard recommendation for post-transplantation anemia (PTA) has resulted in different anemia approaches among transplant centers. The information of PTA in Thai kidney transplant patients is also lacking. We aimed to study the incidence of PTA during one year after transplantation. Factors associated PTA were investigated in Thai population. We performed a retrospective, cohort study from kidney transplant patients between 2014-2015. The primary objective was the incidence of PTA at one year after transplantation. Pre-defined factors were examined to predict the probability of PTA. Of 259 patients, the PTA incidence at one year after transplantation was 43.6%. Factors that increased risk of anemia included urinary tract infection, UTI (OR 2.170, 95% CI 1.434-3.248, P = 0.001), ganciclovir or valganciclovir (OR 1.522, 95% CI 0.926-2.501, P = 0.097), history of blood transfusion (OR 1.483, 95% CI 1.177-1.868, P = 0.001), history of using recombinant human erythropoietin, rHuEpo (OR 1.381, 95% CI 1.098-1.737, P = 0.006), duration of ESRD (OR 1.032, 95% CI 1.006-1.059, P = 0.015), and recipient’s age (OR 1.019, 95% CI 1.009-1.030, P = 0.001). PTA was a common complication (43.6%) after transplantation in Thai kidney transplant patients. UTI, ganciclovir or valganciclovir, history of blood transfusion, history of using rHuEpo, duration of ESRD as well as recipient’s age are associated with an increased risk of PTA. This information can assist practitioners to recognize the tendency of anemia and promising factors to proper management in our transplant center.
Keyword:
Anemia; Factor; Incidence; Kidney; Transplantation
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