[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 41(3),

Pandanus amaryllifolius Root Extract Prolongs Sleeping Time and Reduces Locomotor Activity in Mice

P. Peungvicha*, Y. Wongkrajang, B. Kongsaktrakoon , R. Temsiririrkul and H. Watanabe


The investigation on locomotor activity and hypnotic effect of the decoction of Pandanus amaryllifolius root was performed in mice. The extract at doses of 1- 2 g/kg significantly decreased the spontaneous locomotor activity in a dose-dependent manner during 30 minutes after feeding. The extract at the dose of 4 g/kg significantly suppressed the locomotor activity in amphetamine-treated mice but the lower dose cannot. In addition, the extract at doses of 0.5-2 g/kg feeding prolonged the pentobarbital-induced sleeping time in both sexes of mice. This effect was not attenuated by flumazenil (a selective benzodiazepine receptor antagonist).These results suggest that the water extract of Pandanus amaryllifolius root suppressed the spontaneous and amphetamine-activated locomotor activity. The extract also potentiated the effect of pentobarbital sodium on sleep which is not implicated with benzodiazepine receptor system.


Pandanus amaryllifolius, Toei-hom, Sleeping time, Flumazenil, Locomotor activity, Methamphetamine

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