[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 41(1),
 

Therapeutic Potential of SGLT2 Inhibitors in Treating Type 2 Diabetes Mellitus

M. Amin and N. Suksomboon*

-


Current therapies in type 2 diabetes management lose their efficacy because of their dependence on ?-cell function which decreases with the passage of time. In kidneys, filtered glucose is reabsorbed mostly by the sodium glucose cotransporter-2 (SGLT-2) proteins which are located in the S1 segment of proximal convoluted tubules. SGLT2 inhibitors reduce this reabsorption process by blocking SGLT2 proteins and reduce glycemic levels by promoting urinary glucose excretion which is an insulin independent phenomenon. This loss of glucose in urine is also associated with decrease in body weight by creating an energy deficit and to some extent reduction in blood pressure due to an osmotic diuretic effect. This review focuses on therapeutic potential of SGLT2 inhibitors with a view to identify their role in diabetes management. The available evidence suggests that SGLT2 inhibitors are safe, efficacious and well tolerated across a large group of patients. Provided that the long term safety of this class is established, it is very likely that these agents shall assume a major role in diabetes management.


Keyword:

Type 2 diabetes mellitus, HbA1c, Sodium glucose cotransporter-2, Dapagliflozin, Canagliflozin, Ipragliflozin.




Download full paper (PDF File size: 2,182.04 KB.)





Vol.41
No.4
October - December 2014

See other volume

 


Vol.41
No.3
July - September 2014

See other volume

 


Vol.41
No.2
April - June 2014

See other volume

 


Vol.41
No.1
January - March 2014

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND