[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 41(2),

An Investigation into the Characteristics of Natural Polysaccharide: Polymer Metoprolol Succinate Tablets for Colonic Drug Delivery

G.R. Godge* and S.N. Hiremath


Colon-specific drug delivery systems based on a polysaccharide: polymers blend viz. guar gums, Kollicoat MAE 30 DP were evaluated using in vitro methods. In vitro drug release studies have shown that prepared formulations in the form of compression coat applied over metoprolol succinate (MS) core tablets protected the drug from being released under conditions mimicking mouth to colon transit. The prepared tablets were compression coated with polysaccharide: polymers blend to give protection in the stomach. The coated tablets were tested in vitro for their suitability as colon specific drug delivery systems. The drug release studies were carried out in simulated stomach environment (pH 1.2) for 2 h followed by small intestinal environment at pH 6.8. The result demonstrates that matrix tablets formulated using polysaccharide: polymers blend was unable to prevent the release of drug in upper part of GIT, whereas, compression coated tablets of drug with polysaccharide: polymers blend at different weight ratios (CT1;1.75:0.75, CT2;1.5:1, CT3;1.25:1.25) were shown promising results. The compression coated MS tablets coated with CT1 did not degrade in simulated colonic fluids and showed only 8.03% and 57.39% drug released in the first 6 h and 24 h respectively. When used in different concentrations CT2 and CT3 tablets showed 10.05% & 64.98% and 9.78 &85.73% drug released in the first 6 h and 24 h, respectively. The above study shows that polysaccharide: polymers blend could be successfully used as a rate controlling membrane, for colon targeting of water soluble drugs in preference to guar gum when used in the various concentrations. Additionally, formulations developed with guar gum and Kollicoat MAE 30 DP would be highly site specific since drug release would be at a retarded rate till microbial degradation or polymer solubilization takes place in the colon.


Polysaccharide, Matrix tablets, Simulated colonic fluids, Site-specific, Solubilization.

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