[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 41(2),

Economic Evaluation of Colorectal Cancer Screening: A Systematic Review

K. Kittrongsiri and U. Chaikledkaew*


Colorectal cancer (CRC) is a major public health problem worldwide. CRC screening in average-risk population aims to prevent new cases of CRC by detecting and removing pre-malignant lesions or to discover CRC at its early stage. Implementation of CRC screening program requires enormous of resources; therefore, it is important to carefully assess value for money of the program. Thus, the objective of this study aimed to systematically review the economic evaluation studies of different CRC screening methods in order to identify the optimal screening modality. A systematic review was carried out using PubMed Science Direct and Centre for Reviews and Dissemination (CRD) databases. Full economic evaluations assessing CRC screening in average-risk population from January 2003 to July 2013 were retrieved. Eighteen publications identifying optimal screening modalities were included in the review. Of 18 included studies, the studies were performed in ten different countries used four modeling approaches. Fifty six percent of included studies used cost-utility analysis, whereas the others used cost-effectiveness analysis. The method of gFOBT was the most assessed option, while FIT-biennial screening was the most reported optimal strategy. It was found that CRC screening was considered as a cost-effective or even cost-saving when compared with no screening. Although, the studies did not find the consensus conclusion on which screening method was the most effective or the modality of choice. Of implementing screening program in the country, the evaluation should be conducted to assess the benefits against the society acceptable costs because the transferability of results from one setting to another is limited.


Corolectal cancer, Screening, Economic evaluation

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