อยากทราบว่าsalbutamolและ terbutalineใช้ต่างกันอย่างไรค่ะ

คำตอบ

Salbutamol(albuterol) และ terbutaline เป็นยาในกลุ่ม beta2 adrenergic agonist มีข้อแตกต่างกันดังนี้ • Pharmacologic and pharmacokinetic properties agent beta2 potency1 route Onset (minute) Duration (hrs.) Pregnancy risk factor albuterol 2 PO Within 30 4-8 C Inh Within 5 3-6 terbutaline 4 PO 30 4-8 B SC 5-15 1.5-4 Inh 5-30 3-6 1 Relative molar potency: 1 = most potent • Adverse reactions (≥3%)1 Adverse reaction albuterol terbutaline 1. Cardiovascular Palpitations  1-10 ≤ 23 Tachycardia 1-10 1.3-3 BP changes/hypertension 1-5  1 Chest tightness/pain/discomfort, angina  3 1.3-1.5 PVCs, arrhythmias, skipped beats  4 2. CNS Tremor  1-24.2  5-38 Dizziness/vertigo  1-7 1.3-10 Shakiness/nervousness/tension 1-20  5-31 Drowsiness  1  5-11.7 Hyperactive/hyperkinesias, excitement 1-20 Headache 2-22 7.8-10 Insomnia 1-11  3. GI Nausea/vomiting 2-15 1.3-10 Heartburn/ GI distress/ disorder ≤ 5  10 Diarrhea 1 4. Respiratory Cough  1-5 Bronchospasm 1-15.4 Throat dryness/ irritation, pharyngitis ≤ 6  1 Data pooled for all routes of administration, all age groups, from separate studies, and are not necessarily comparable. 2  = Report; no incidence given.

Reference:
www.thomsonhc.com
Drug facts and Comparisons Pocket Version, 7 th edition 2003
Drug Information Handbook 15th edition 2008

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