[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


DOI: https://doi.org/10.14456/mujps.2015.24Pharm Sci Asia 2015; 42(4), 195-202

Investigation on hospital-acquired pneumonia and the association between hospital-acquired pneumonia and chronic comorbidity at the Department of General Internal Medicine, University Medical Center Hochiminh City

MT. Nguyen, TD. Dang Nguyen*

- Department of Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy, Hochiminh City, Vietnam

Hospital-acquired pneumonia (HAP) is the most common cause of death among nosocomial infections. Controlling for risk factors, especially comorbid conditions plays an important role in the prevention and management of HAP. The Chronic Disease Score (CDS) has been widely used as a tool for comorbidity measurement of chronic diseases. However, little is known about the use of CDS in estimating the impact of comorbidity on infectious conditions. This descriptive cross-sectional study aims at describing the charateristics of HAP patients, the use of antibiotics and identifying the association between chronic comorbidities using CDS and treatment outcome among patients with HAP. The study population included 213 patients diagnosed with HAP admitted to the Department of General Internal Medicine, University Medical Center Hochiminh city from October 1st 2014 to March 31st 2015. The mean CDS score was 4.9, ranging from 0 to 15. The most common pathogen associated with early-onset pneumonia (NP) is Streptococcus spp. whereas Acinetobacter spp. is the most common pathogen found in late-onset NP. Third generation cephalosporins and quinolones were markedly resistant. The combination of two antibiotics accounted for 65.3% of cases treated with antibiotic empiric therapy. Multivariable logistic regression analysis identified that cancer (OR = 4.95; 95% CI 1.46-16.76), CDS score (OR = 0.832; 95% CI 0.71 - 0.97), age from 45 to 64 (OR = 14.09; 95% CI 6.77 - 21.96), age 65 and above (OR = 15.13; 95% CI 7.87-15.92) and mechanical ventilation (OR = 5.05; 95% CI 1.23 - 20.60) were associated with failure in treatment outcome.


chronic disease score, comorbidity, hospital-acquired pneumonia

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