[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: https://doi.org/10.14456/mujps.2015.16Pharm Sci Asia 2015; 42(3), 126-134
 

Chemical and physical stability investigations of captopril extemporaneous suspension for oral administration

N. Sathapanapitagkit1, M. Prokati1, J. Leanpolchareanchai1,2, D. Chantasart1,2, M. Laohajeeraphan3, J. Suksiriworapong1,2*

1 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
2 Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
3 Pharmacy Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand


Captopril is frequently used for hypertension and heart failure in pediatrics. In Thailand, no captopril liquid formulation is available because of its instability. The aim of our study was to develop the physically and chemically stable captopril extemporaneous suspension. The captopril suspension was prepared by grinding captopril tablets and triturating with syrup 80% w/v to the desired volume resulting in 1 mg/mL captopril suspension. For the formulations containing stabilizers, citric acid 2% w/v, vitamin C tablets 4 and 5 mg/mL were triturated with the ground captopril tablet before mixing with the vehicle. All formulations were kept in amber bottles at 2-8oC for 90 days and 30oC for 60 days. At each time point, the appearance, pH and number of redispersibility were evaluated for the physical stability. For the chemical stability, the amounts of captopril and dimer were quantified. The addition of vitamin C increased the number of redispersibility and minimally lowered the pH of formulations. Citric acid decreased the pH of formulation from 4.53-4.67 to 2.50-2.80. As the storage time increased, the number of redispersibility and the dimer content increased while the captopril amount reduced. The increased concentration of vitamin C had no effect on the stability. Obviously, the increasing storage temperature decreased the chemical stability. At 2-8?C, the addition of all stabilizers could preserve the amount of captopril over 90% for 90 days whereas the drug in the formulation without stabilizer remained over 90% for 74 days. At 30?C, the drug content was less than 90% after 28 days.


Keyword:

Captopril, Extemporaneous preparation, Stabilizer, Suspension, Syrup




Download full paper (PDF File size: 933.98 KB.)





Vol.42
No.4
October - December 2015

See other volume

 


Vol.42
No.3
July - September 2015

See other volume

 


Vol.42
No.2
April - June 2015

See other volume

 


Vol.42
No.1
January - March 2015

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND