[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 31(2),

The Effect of Mallotus repandus (Willd.) Muell.-Arg. on Cytokine Levels

Kwanchai Rattanamanee, Chuthamanee Suthisisang and Noppamas Soonthornchareonnon


The stem of Mallotus repandus (Willd.) Muell.-Arg. has been used for musculoskeletal pain in Thai
traditional medicine for many years. The ethanolic extract of the dry stem of M. repandus and bergenin, the major
compound isolated from this plant, were evaluated for their effects on inflammatory cytokine (TNF-£\\, IL-1£] and
IL-10) levels by using human whole blood method. The ethanolic extract exhibited significant reduction in the
proinflammatory cytokines (TNF-£\\ and IL-1£]). In contrast, it induced a significant increase in IL-10 which is an
antiinflammatory cytokine. Bergenin slightly affect the cytokine concentrations. It is concluded that reducing
proinflammatory cytokines, TNF-£\\ and IL-1£], as well as increasing the level of antiinflammatory cytokine IL-10
was one of the mechanisms of the antiinflammatory activity of the ethanolic extract of M. repandus explored in
this study. ∆…All rights reserved.


Cytokine, Mallotus repandus ,musculoskeletal pain , bergenin, inflammatory cytokine ,proinflammatory cytokines ,IL-10

July-December 2004

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January-June 2004

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