[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 31(1),

Antiinflammatory Activity of Solanum trilobatum Linn. Fruit Extracts

Suchitra Thongpraditchote, Yuvadee Wongkrajang, Rungravi Temsiririrkkul and Boontium Kongsaktrakoon


The antiinflammatory activity of Solanum trilobatum L. (S. trilobatum) or “Mawaeng krueo” fruit extracts was studied using the carrageenan-induced hind paw edema model in rats. S. trilobatum fruits were extracted by three different solvents, i.e. water (water extract), 95% ethanol (ethanolic extract) and 95% ethanol : HCl (10:1) (acidic extract). Oral administration of all extracts at a dose of 600 mg/kg significantly reduced rat paw edema at 1 hour after inflammatory induction (p < 0.05). The water extract of S. trilobatum exhibited a significant antiinflammatory effect (p < 0.05) only at 1 hour after carrageenan injection while the ethanolic extract showed a significant inhibition of rat paw edema at 1, 2 and 3 hours (p < 0.05). Like diclofenac, the acidic extract exhibited a significant reduction of the paw edema throughout a period of study for 5 hours. However, the extract possessed a less potent antiinflammatory activity than the reference drug. In conclusion, the present results demonstrate antiinflammatory activity of the extracts of S. trilobatum fruits.


Antiinflammatory Activity ,Solanum trilobatum Linn. ,Mawaeng krueo, carrageenan,paw edema ,diclofenac

July-December 2004

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January-June 2004

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