[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 29(2),
 

New leads of HIV-1 Integrase Inhibitors

Opa Vajragupta and Preecha Boonchoong

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Following to reverse transcriptase (RT) and protease (PR), integrase (IN) has emerged as an attractive target for new anti-HIV-1 agents. IN was found to be promising candidate because of its necessary for viral life cycle and lack of IN homologous enzymes in the human host. Different classes of HIV-1 IN inhibitors have been reported, for example, aryl 1,3-diketo-containing compounds, hydrazide-containing compounds, styrylquinoline derivatives, L-chicoric acid analogues, thiazolothiazepine derivatives and other hydroxylated compounds including bis-catechols and curcumin. The important structural features that are essential for the inhibition of the integrase are pointed out in this review.


Keyword:

HIV-1 Integrase Inhibitors ,reverse transcriptase , protease ,integrase,anti-HIV-1 agents








Vol.29
No.3-4
September-December 2002

See other volume

 


Vol.29
No.1-2
January-August 2002

See other volume

 
 
 

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