[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 29(1),

Permeability of Silicone Membrane to Model Solutes.

Pojawon Lawanprasert, Puangkaew Lukkanatinaporn, Narong Sarisuta


Silicone membrane permeation of model solutes were studied. It was found that physicochemical parameters, namely an intrinsic molecular volume and solvatochromic parameters, can be used to determine the rate and extent of model solutes penetration across the silicone membrane. A mathematical model used for quantitative prediction of the permeation charateristics of solute across the model membrane has been proposed. Prediction of permeability coefficient of chlorocresol has been carried out using this equation. It was shown that the predicted value closely approximate the actual value. Additionally, this model also provides useful insight into the complex nature of permeation process through silicone membrane


Silicone Membrane,intrinsic molecular volume,solvatochromic parameters,chlorocresol

September-December 2002

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January-August 2002

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