[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 29(1),
 

Neuroprotection of Hydroxynicotinyl Amide 18 against Lipid Peroxidation and Memory Impairment.

Opa Vajaragupta, Orawan Monthakantirat, Preecha Boonchoong, Hiroshi Watanabe, Penchom Peungvicha

-


Hydroxynicotinyl amide 18, a novel radical-scavenging agent, was developed for neuroprotection. 18 showed substantial ex vivo inhibitory action against lipid peroxidation in mice brain regardless of low in vitro inhibition. These indicated that 18 effectively reached the brain, the target site. Electron paramagnetic resonance (EPR) verified the scavenging ability of 18 by showing suppression of the HO? and O2?? radicals resulting in the decrease of signal areas of PBN/OH and DMPO/OOH, respectively. Neuropharmacology of 18 was investigated in mice in comparison with chroman amide 12P, a potent neuroprotective-radical scavenger. 18 at 100 mg/kg, i.p. was the promising compound as it showed significant suppression (18.16%) on the hypermotility induced by methamphetamine (MAP), but did not reduce locomotor activity in normal condition as 12P did. The suppression demonstrated the enhancement of brain delivery and the antagonism against aberrant dopamine release. In water maze test, 18 (100 mg/kg, i.p.) as well as 12P (200 mg/kg) and tacrine (3 mg/kg), significantly reduced the learning and memory impairment induced by scopolamine (0.5 mg/kg), 18 was more potent than 12P. These results support the enhanced brain delivery of 18 as well as provide additional evidence for the role of radical scavenger in the modulation of brain neurotransmitters in the aberrant condition.


Keyword:

Neuroprotection, Neuroprotection, Lipid Peroxidation ,Memory Impairment,radical-scavenging agent,methamphetamine,neuroprotective








Vol.29
No.3-4
September-December 2002

See other volume

 


Vol.29
No.1-2
January-August 2002

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND