Academic Staff

Prof. Dr. Opa Vajragupta Prof. Dr. Opa Vajragupta opa.vaj@mahidol.ac.th opa.vaj@mahidol.ac.th Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University.

2021

1. Synthesis, characterization and antimalarial activity of isoquinoline derivatives

   Theeramunkong S*, Thiengsusuk A, Vajragupta O, Muhamad P. Medicinal chemistry research 2021; 30(1): 109-119.
   
   

2020

1. α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling.

   Witayateeraporn W, Arunrungvichian K, Pothongsrisit S, Doungchawee J, Vajragupta O, Pongrakhananon V*. Biochem biophys res commun 2020; 521(4): 977-983.
   
   

2. In silico finding of key interaction mediated α3β4 and α7 nicotinic acetylcholine receptor ligand selectivity of quinuclidine-triazole chemotype

   Arunrungvichian K, Chongruchiroj S, Sarasamkan J, Schüürmann G, Brust P, Vajragupta O*. International journal of molecular sciences 2020; 21(17): 6189: 1-18.
   
   

3. Lead discovery of a guanidinyl tryptophan derivative on amyloid cascade inhibition

   Suwanttananuruk P, Jiaranaikulwanitch J*, Waiwut P, Vajragupta O. Open chemistry 2020;18(1): 546-548.
   
   

2017

1. Design and synthesis of caffeic amides by structure-based approaches

   Mudjupa C, Theeramunkong S, Vajragupta O*. Chiang Mai Journal of Science 2017; 44(2): 617-629.
   
   

2. Neuritogenic activity of bi-functional bis-tryptoline triazole

   Jiaranaikulwanitch J*, Tadtong S, Govitrapong P, Fokin VV, Vajragupta O. Bioorganic and Medicinal Chemistry 2017; 25(3): 1195-1201
   
   

3. Radiosynthesis of (S)-[18F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors

   Sarasamkan J, Fischer S, Deuther-Conrad W, Ludwig F-A, Scheunemann M, Arunrungvichian K, Vajragupta O, Brust P*. Applied Radiation and Isotopes 2017; 124: 106-113.
   
   

2016

1. Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies.

   Phowichit S, Kobayashi M, Fujinoya Y, Sato Y, Sanphanya K, Vajragupta O, Chularojmontri L, Wattanapitayakul SK*. Molecules. 2016; 21(9): E1258.
   
   

2. Design and Synthesis of Nicotinic Acetylcholine Receptor Antagonists and their Effect on Cognitive Impairment

   Jaikhan P, Boonyarat C, Arunrungvichian K, Taylor P, Vajragupta O*. Chemical Biology & Drug Design 2016; 87(1): 39-56.
   
   

3. Development and validation of high-performance liquid chromatography method for determination of miconazole, triamcinolone, methylparaben and propylparaben in cream

   Ei ZZ, Pimthon J, Vajragupta O, Leanpolchareanchai J, Phechkrajang CM*. Mahidol University Journal of Pharmaceutical Sciences 2016; 43 (4): 211-221
   
   

4. Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood-brain barrier model

   Srimanee A*, Regberg J, Hällbrink M, Vajragupta O, Langel Ü. International Journal of Pharmaceutics 2016; 500(1): 128-135.
   
   

5. Synthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agents

   Theeramunkong S*, Vajragupta O, Mudjupa C. Medicinal Chemistry Research 2016; 25(12): 2959-2964.
   
   

6. Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds.

   Sarasamkan J, Scheunemann M, Apaijai N, Palee S, Parichatikanond W, Arunrungvichian K, Fischer S, Chattipakorn S, Deuther-Conrad W, Schüürmann G, Brust P, Vajragupta O. ACS Medicinal Chemistry Letters 2016; 7(10): 890-895.
   
   

2015

1. Cognitive improvement in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.

   Arunrungvichian K, Boonyarat C, Fokin VV, Taylor P, Vajragupta O*. ACS Chemical Neuroscience 2015, 6(8):1331-40.
   
   

2. Effect of N-terminal truncation on antibacterial activity, cytotoxicity and membrane perturbation activity of Cc-CATH3

   Jittikoon J*, Ngamsaithong N, Pimthon J, Vajragupta O. Archives of Pharmacal Research 2015; 38(10): 1839-1849
   
   

3. Lead compound bearing caffeic scaffold induces EGFR suppression in solid tumor cancer cells

   Mudjupa C, Abdelhamed S, Refaat A, Yokoyama S, Saiki I, Vajragupta O*. Journal of applied biomedicine 2015; 13(4): 305-317
   
   

4. Selectivity Optimization of Substituted 1,2,3-Triazoles as α7 Nicotinic Acetylcholine Receptor Agonists

   Arunrungvichian K, Fokin VV, Vajragupta O*, Taylor P. ACS Chemical Neuroscience 2015; 6(8): 1317-1330
   
   

2014

1. Development of Chemometric Tool for Determination of Peptide Samples Comparing with High-Performance Liquid Chromatography

   Phechkrajang C, Jarusintanakorn S, Vajragupta O. Mahidol University Journal of Pharmaceutical Sciences 2014; 41 (4), 18-28
   
   

2. Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways.

   Boonyarat C, Yenjai C, Vajragupta O, Waiwut P*. Asian Pacific Journal of Cancer Prevention 2014; 15(23): 10483-10487
   
   

3. Peptide-based delivery of oligonucleotides across blood-brain barrier model

   Srimanee A*, Regberg J, Hallbrink M, Kurrikoff K, Veiman K.-L, Vajragupta O, Langel U. International Journal of Peptide Research and Therapeutics 2014; 20(2): 169-178
   
   

4. Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

   Thiratmatrakul S, Yenjai C, Waiwut P, Vajragupta O, Reubroycharoen P, Tohda M, Boonyarat C*. European Journal of Medicinal Chemistry 2014; 75: 21-30
   
   

2013

1. Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach

   Sanphanya K, Wattanapitayakul SK, Phowichit S, Fokin VV, Vajragupta O*. Bioorganic and Medicinal Chemistry Letters 2013; 23(10): 2962-2967
   
   

2. Synthesis, Topoisomerase I Inhibitory and Cytotoxic Activities of Chromone Derivatives

   Maicheen C, Jittikoon J, Vajragupta O, Ungwitayatorn J*. Medicinal Chemistry 2013; 9(3): 329-339
   
   

2012

1. Antibacterial Activity of Cc-CATH3 Peptide and its N-terminally Truncated Analogues against Gram-positive and Gram-negative Bacteria.

   Ngamsaithong N, Pimthon J, Vajragupta O, Jittikoon J*. Mahidol University Journal of Pharmaceutical Sciences 2012; 39(2): 1-6
   
   

2. From BACE1 Inhibitor to Multifunctionality of Tryptoline and Tryptamine Triazole Derivatives for Alzheimer’s Disease

   Jiaranaikulwanitch J, Govitrapong P, Fokin VV, Vajragupta O*. Molecules 2012; 17(7): 8312-8333
   
   

3. Molecular Dynamics and Experimental Investigations of Membrane Perturbation by Ceragenin CSA-13

   Jueati R, Jittikoon J, Vajragupta O, Pimthon J*. Mahidol University Journal of Pharmaceutical Sciences 2012; 40(2): 25-32
   
   

4. Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents

   Sanphanya K, Wattanapitayakul SK, Prangsaengtong O, Jo M, Koizumi K, Shibahara N, Priprem A, Fokin VV, Vajragupta O*. Bioorganic and Medicinal Chemistry Letters 2012; 22(8): 3001-3005
   
   

5. The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor

   Rojsanga P, Boonyarat C, Utsintong M, Nemecz A, Yamauchi JG, Talley TT, Olson AJ, Matsumoto K, Vajragupta O*. Life Sciences 2012; 91(3 มิ.ย.): 107-114
   
   

6. Virtual screening against acetylcholine binding protein

   Utsintong M, Rojsanga P, Ho K-Y, Talley TT, Olson AJ, Matsumoto K, Vajragupta O*. Journal of Biomolecular Screening 2012; 17(2): 204-215
   
   

2011

1. Antifungal, cytotoxic activities and docking studies of 2,5-dimercapto-1,3,4-thiadiazole derivatives

   Samee W*, Vajragupta O. African Journal of Pharmacy and Pharmacology 2011; 5(4): 477-485
   
   

2010

1. Authentication of coscinium fenestratum among the other menispermaceae plants prescribed in Thai folk medicines.

   Watthanachaiyingcharoen R, Komatsu K, Zhu S, Vajragupta O, Leelamanit W*. Biol Pharm Bull 2010; 33(1): 91-94.
   
   

2. Triazolyl tryptoline derivatives as β-secretase inhibitors

   Jiaranaikulwanitch J, Boonyarat C, Fokin VV, Vajragupta O*. Bioorg Med Chem Lett. 2010: 20(22): 6572-6576.
   
   

2009

1. 5-substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor

   Kammasud N, Boonyarat C, Sanphanya K, Utsintong M, Tsunoda S, Sakurai H, Saiki I, André I, Grierson DS, Vajragupta O*. Bioorg Med Chem lett 2009 ;19(3):745-50.
   
   

2. Rediocides A and G as potential antitoxins against cobra venom

   Utsintong M, Kaewnoi A, Leelamanit W, Olson AJ, Vajragupta O*. Chem Biodivers 2009; 6(9): 1404-1414.
   
   

3. Virtual screening against {alpha}-cobratoxin

   Utsintong M, Talley TT, Taylor PW, Olson AJ, Vajragupta O*. J Biomol Screen 2009; 14(9): 1109-1118.
   
   

2007

1. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus

   Sumanont Y, Murakami Y,Tohda M , Vajragupta O, Watanabe H, Matsumoto K*. Biol Pharm Bull 2007;30(9) Sep: 1732—1739
   
   

2006

1. A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action

   Vajragupta O*, Boonyarat C, Olson AJ, Murakami Y, Tohda M, Matsumoto K, Watanabe H. Free Radic Res 2006; 40(7): 685-95.
   
   

2. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin.

   Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Watanabe H, Matsumoto K*. Life Sci 2006; 78(16): 1844-1849.
   
   

2005

1. Active site binding modes of curcumin in HIV-1 protease And integrase

   Vajragupta O*, Boonchoong P, Morris MG, and Olson JA. Bioorganic & Medicinal Chemistry letters 2005; 15(14): 3364-3368
   
   

2004

1. Antoixidant activity of Limnophila aromatica Merr

   Sribusarakum A, Bunyapraphatsara N, Vajragupta O, Watanabe H Thai J Phytopharm 2004;11(2):11-17
   
   

2. Evaluation of the nitric oxide radical scavenging activity of manganese complexes of curcumin and its derivative

   Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Matsumoto K, Watanabe H*. Biol Pharm Bull 2004;27(2):170-3.
   
   

3. Manganese complexes of curcumin analogues: evaluation of hydroxyl radical scavenging ability, superoxide dismutase activity and stability towards hydrolysis.

   Vajragupta O*, Boonchoong P, Berliner LJ Free Radic Res 2004 Mar;38(3):303-14.
   
   

2003

1. Amides from natural acids against oxidative Stress.

   Vajragupta O, Utsintong M, Peungvicha P, Watanabe H Mahidol J Pharm Sci 2003;30(2):27-36
   
   

2. Cytoprotective and cytotoxic effects of curcumin: Dual action on H2O2-induced oxidative cell damage in NG108-15 cells.

   Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H*, Vajragupta O. Biol Pharm Bull 2003; 26(5): 725-8
   
   

3. Effect of pH, buffer concentration ionic strength and temperature on ketoconazole stability in acidic solutions.

   Junyaprasert VB, Techowanich S, Vajragupta O, Mitrevej A. Mahidol J Pharm Sci 2003;30(2):17-36
   
   

4. Maganese complexes of curcumin: Radical scavenger and neuroprotective agents.

   Vajragupta O,Boonchoong P, Watanabe H, Tohda M, Kummasud N, Sumanont Y. Free Radic Res 2003; 37: 49 (suppl 1)
   
   

5. Manganese complexes of curcumin analogues: Evalution of hydroxyl radical scavenging ability, superoxide dismutase activity and stability towards hydrolysis

   Boonchoong P, Vajragupta O, Berliner LJ. Free Radic Res 2003; 37: 51 (suppl 1)
   
   

6. Manganese complexes pf curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity.

   Vajragupta O*, Boonchoong P, Watanabe H, Tohda M, Kummasud N, Sumanont Y. Free Radic Biol Med35(12):1632-44, 2003; 35(12): 1632-1644
   
   

7. Manganese-Based Complexs of Radical Scavengers as Neuroprotective Agents.

   Vajragupta O*, Boonchong P, Yaowared S,Hiroshi W, Wongkrajang Y, Kammasud N. Bioorganic & Medicinal Chemistry 2003;11:2329-2337
   
   

2002

1. Neuroprotection of Hydroxynicotinyl Amide 18 against Lipid Peroxidation and Memory Impairment.

   Vajragupta O, Monthakantirat O, Boonchong P, Watanabe H, Peungvicha P. Mahidol J Pharm Sci 2002; 29: 33-43
   
   

2. New leads of HIV-1 Integrase Inhibitors

   Vajragupta O,Boonchoong P Mahidol J Pharm Sci 2002; 29(3-4)
   
   

2000

1. Chromanamide 12 : inhibition of lipid peroxidation and protection against learning and memory impairment.

   Vajragupta O*, Monthakanrat O, Wongkrajang, Y, Watanabe H, Peungvicha P Life Sci 2000; 67(14): 1725-1734
   
   

2. Chromanamide and nicotinyl amide derivatives : inhibition of lipid peroxidation and protection against head trauma

   Vajragupta O*, Toasaksiri S, Boonyarat C, Wongkrajang Y, Peungvicha P Free Radic Res 2000; 32(2): 145-155
   
   

3. Comparative quantitative structure-activity study of radical scavengers.

   Vajragupta O*, Boonchoong P, Wongkrajang Y. Bioorg Med Chem 2000; 8(11): 2617-2628
   
   

1997

1. Differential scanning colorimeter in purity determination on pharmaceutical raw material.

   Vajragupta O, Silapakalpradit W, Pitijomwong W, La-ong S. J Ind Pharm 1997; 2(2): 29-37
   
   

1996

1. Betacarotene serum profile after single dose adminstration of betacarotene capsule v.s. carrot.

   Chindavijak B, Sornsuvit C, Vajragupta O, Pattamakom V. Thai J Phytopharm 1996; 3:7-15
   
   

2. Synthesis and antihypertensive activity of N-(Alkyl/alkenyl/aryl)-N-heterocyclic ureas and thioureas.

   Vajragupta O, Pathomsakul A, Matayatsuk C, Rungreuangyingyod L, Wongkrajang Y, Foye OW. Journal of Pharmaceutical Sciences 1996; 85 (3): 258-61
   
   

1995

1. 24 hour serum level after a single dose administration of beta-carotene capsule.

   Chindavijak B, Soontornpass C, Vajragupta O Mahidol J Pharm Sci 1995; 22:92-100
   
   

1993

1. Synthesis and skin permeation study of lidocaine organic salts.

   Vajragupta O, La-ong S. Drug Dev Ind Pharm 1993;20:2671-84
   
   

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หมายเหตุ: ชื่อที่ใช้ในการทำวิจัยของ Prof. Dr. Opa Vajragupta ได้แก่ โอภา วัชระคุปต์ ; Vajragupta O ;