[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2022.03.21.149Pharm Sci Asia 2022; 49(3), 249-256
 

Terminalia arjuna flowers: Secondary metabolites and antifungal activity

Ahlam Hashem Elwekeel1, Elham Amin1,2, Ahmed Khairallah3, Abeer Sayed Moawad1*

1 Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt
2 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia
3 Department of Pharmaceutical Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt


Fungal pathogens are able to cause serious infections to human. Candidiasis caused by Candida species and pulmonary aspergillosis caused by Aspergillus fumigatus may occur as secondary complication in immunocompromised patients. Meanwhile, biologically guided isolation of bioactive constituents from natural sources represents a promising strategy in drug discovery process. In this concern, the antimicrobial screening of 11 plants collected from Egypt was performed against several microbes. Terminalia arjuna flower extract was among the most active extracts against C. albicans. The antifungal potential of n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc) fractions of T. arjuna flower were tested against C. albicans, A. fumigatus and Fusarium avenaceum. Results revealed a potent activity of EtOAc extract against C. albicans (100% inhibition, MIC=7.81 µg/mL). Chromatographic investigation of T. arjuna flower afforded nine compounds; β-sitosterol (1), stigmasterol (2), β-sitosterol-3-O-β-D-glucopyranoside (3), rosamultin (4), niga-ichigoside Fl (5), luteolin (6), apigenin (7), gallic acid (8) and methyl gallate (9). The structures of the isolated compounds were elucidated using different spectroscopic techniques especially 1D and 2D NMR. Among the isolated compounds, the two triterpenoid glycosides (4) and (5) have not been previously tested for antifungal potential. The current study indicated moderate activity of rosamultin (4) and niga-ichigoside Fl (5) (MIC 250 µg/mL) against C. albicans.


Keyword:

Terminalia arjuna flower, Candida, Aspergillus fumigatus, Rosamultin, Niga-ichigoside Fl




Download full paper (PDF File size: 1,220.10 KB.)

Download supporting file (PDF File size: 2,755.64 KB.)





Vol.49
No.6
November-December 2022

See other volume

 


Vol.49
No.5
September-October 2022

See other volume

 


Vol.49
No.4
July-August 2022

See other volume

 


Vol.49
No.3
May-June 2022

See other volume

 


Vol.49
No.2
March-April 2022

See other volume

 


Vol.49
No.1
January-February 2022

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.