[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2022.02.21.106Pharm Sci Asia 2022; 49(2), 147-152
 

Assessment of direct-acting oral anticoagulants for the treatment of venous thromboembolism in cancer patients in Thai Tertiary Care Hospital

Jennis Meanwatthana1*, Phatcharin Mitsuntisuk2

1 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
2 Pharmacy Unit, Police General Hospital, Bangkok, Thailand


Venous thromboembolism (VTE) is an important cancer complication. Recent studies suggest direct-acting oral anticoagulants (DOACs) are possible alternatives for this population; nonetheless, there is limited evidence to support this decision in Thai cancer patients. The primary aim of this study was to measure the cumulative incidence of VTE recurrences and major bleeding among cancer patients who received DOACs that were available in Thailand. Secondary objective was to determine factors associated recurrent VTE and major bleeding. This is a retrospective cohort study conducted in tertiary care hospitals in Thailand. Data was collected from patients who had active cancer with new diagnosis of VTE and receiving approved DOACs. There were 32 cases, who received rivaroxaban, apixaban, or dabigatran, recruited to this study. We reported 4 cases (12.5%) of recurrent VTE at 6-month. There were 6 patients (18.75%), 2 patients (6.25%), and 1 patient (3.13%) with major bleeding, minor bleeding and intracranial hemorrhage, consecutively. No correlation was found between factors associated with recurrent VTE recurrence or bleeding. This study demonstrated that DOACs may be an acceptable option for preventing VTE recurrence. However, Thai population may be potentially prone to have clinically relevant bleeding. A further prospective study is warranted to draw a final conclusion in Thai cancer patients.


Keyword:

Direct-acting oral anticoagulant, Cancer-associated thrombosis, VTE, Venous thromboembolism, Malignancy




Download full paper (PDF File size: 832.74 KB.)





Vol.49
No.6
November-December 2022

See other volume

 


Vol.49
No.5
September-October 2022

See other volume

 


Vol.49
No.4
July-August 2022

See other volume

 


Vol.49
No.3
May-June 2022

See other volume

 


Vol.49
No.2
March-April 2022

See other volume

 


Vol.49
No.1
January-February 2022

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.