[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2022.02.21.133Pharm Sci Asia 2022; 49(2), 161-168
 

Study of weight variation and dissolution of Edoxaban split tablets in pharmacy practice

Mantiwee Nimworapan1*, Sinwisuth Sutheechai1, Wanwarang Wongcharoen2, Arintaya Phrommintikul2, Suntara Eakanunkul3

1 Department of Pharmaceutical care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
2 Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand


Edoxaban is available in 60 mg, 30 mg, and 15 mg unscored film-coated tablets. Tablet splitting may be an option to reduce medication costs and reduce the country’s budget. The objectives of this study were to determine the weight variation and the dissolution profile of the 60 mg edoxaban in split half-tablets using a pill splitter. Thirty edoxaban 60 mg tablets were cut into halves by a right-handed pharmacist. The weight variation of the whole and half tablets were compared. For the dissolution test, 6 whole tablets and 12 half-tablets were separately dissolved in three dissolution media. Sixty half-tablets of edoxaban had the expected half-tablet weight within the 75% to 125% range that fell within the proxy United States Pharmacopeia (USP). The mean total weight of the 1st and 2nd halves were not significantly different from the mean weight of the intact tablets (p-value=0.216). The amount of drug release from the whole and half tablets in 0.1 N HCl medium was greater than 85% in 15 minutes which met the acceptance criteria for the dissolution test. Edoxaban tablets splitting had low variations in weight. Therefore, edoxaban tablets can be split into halves by a tablet cutter.


Keyword:

Tablet splitting, Edoxaban, Weight variation, Dissolution test




Download full paper (PDF File size: 1,257.83 KB.)





Vol.49
No.6
November-December 2022

See other volume

 


Vol.49
No.5
September-October 2022

See other volume

 


Vol.49
No.4
July-August 2022

See other volume

 


Vol.49
No.3
May-June 2022

See other volume

 


Vol.49
No.2
March-April 2022

See other volume

 


Vol.49
No.1
January-February 2022

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.