| DOI: 10.29090/psa.2022.03.21.184 | Pharm Sci Asia 2022; 49(3), 223-229 |
Intraoperative sedation and postoperative analgesic effects of bupivacaine-dexmedetomidine mixture compared to bupivacaine alone in upper extremity bone surgeries: A randomized comparative study in VietnamNhung Thi Cam Tran1, Khanh Hoang Pham2*, Thang Nguyen2, Dao Huynh Tran3, Hung Xuan Tong4, Chung Van Nguyen5
1 Hoan My Cuu Long Hospital, Can Tho City, Vietnam
2 Can Tho University of Medicine Pharmacy, Can Tho City, Vietnam
3 Can Tho Central General Hospital, Can Tho City, Vietnam
4 108 Military Central Hospital, Hanoi, Vietnam
5 University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
We aimed to compare intraoperative sedation and postoperative analgesic effects of brachial plexus block using bupivacaine-dexmedetomidine mixture (BD) versus bupivacaine alone (B) in upper extremity bone surgeries. We conducted a randomized comparative study at Can Tho City, Vietnam. We recruited patients aged 15 to 75 years, ASA (American Society of Anesthesiology) I-III grade, indicating bone surgeries of arm or forearm with supraclavicular brachial plexus block by ultrasound guidance. One hundred eight included patients were randomly divided into two groups: the BD group (54 patients) received a 30 ml mixture of 0.25% bupivacaine and 100 mcg dexmedetomidine, and the B group (54 patients) received 30 ml of 0.25% bupivacaine. The BD group had a sedative OAA/S score (Observer Assessment of Alertness/Sedation Scale) of level 4, accounting for 87% more than group B 37%, and an OAA/S score of level 3 in the BD group with 5 cases (9.3%) compared with 9 cases (16.7%) in group B, statistically significant difference with p<0.05. The onset and duration of sedative time in group BD was 9.8±3.5 and 92.7±34.1 minutes. The mean of postoperative analgesic time was 970.5±309.5 minutes in group BD statistically significantly longer than group B’s with 552.7±231.2 minutes (p<0.001). In conclusion, a mixture of bupivacaine-dexmedetomidine in brachial plexus block for arm and forearm surgical fractures had greater sedative and postoperative analgesic effects than that of bupivacaine alone.
Keyword:
Brachial plexus block, Bupivacaine, Dexmedetomidine, Intraoperative sedation, Postoperative pain relief, Ultrasound guidance
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