[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: https://doi.org/10.29090/psa.2018.02.114Pharm Sci Asia 2018; 45(2), 114-122
 

Incidence and risk factors for venous thromboembolism in Thai hospitalized lymphoma patients

W. Kunawuttinankorn, K. Tanyasaensook, P. Rojnuckarin

1 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Rajathevi, Bangkok 10400, Thailand
2 Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873 Rama IV Road, Patumwan, Bangkok 10330, Thailand


Venous thromboembolism (VTE) is a common complication in cancer patients. However, the magnitude of this problem in Thai hospitalized lymphoma patients has not been well studied. To identify the incidence and risk factors for VTE in those patients, retrospective and prospective cohort studies were conducted in lymphoma patients admitted to a medical school affiliated hospital. Patient profile and risk factors were recorded. Patients were followed up for 90 days after admission. A total of 469 patients were included, of which 422 patients identified from 2007 to 2011 from hospital electronic data base were in the retrospective cohort, and 47 patients enrolled during 6 months in 2012 were in the prospective cohort. Two patients in the retrospective cohort had unconfirmed VTE, and then were excluded. The incidences of VTE in the retrospective cohort and the prospective cohort were 3.6% and 8.5%, respectively (p=0.113). In the retrospective cohort, VTE rates in Non-Hodgkin’s lymphoma (NHL) and Hodgkin’s lymphoma (HL) patients were 3.4% and 5.9%, respectively (p=0.347). All VTEs in the prospective cohort were in NHL patients. Concerning time to VTE, all events occurred before starting or during the first 3 courses of chemotherapy. Upon multivariate analysis, the independent risk factor for VTE was being bedridden (adjusted odds ratio 6.21, 95% confidence interval 1.59 – 24.31). In conclusion, the incidence of VTE in Thai hospitalized lymphoma patients admitted for chemotherapy is high. This implies that VTE prophylaxis should be considered during the early courses of chemotherapy in bedridden lymphoma patients.



Keyword:

Venous thromboembolism; Lymphoma; Thailand; Hospitalized patients




Download full paper (PDF File size: 413.60 KB.)





Vol.45
No.4
October - December 2018

See other volume

 


Vol.45
No.3
July - September 2018

See other volume

 


Vol.45
No.2
April - June 2018

See other volume

 


Vol.45
No.1
January - March 2018

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND