[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974


Pharm Sci Asia ; 39(3),

Development of Chromatographic Technique for Simultaneous Estimation of Lovastatin and Diltiazem Hydrochloride

A. S. Kulkarni1, S. D. Jadhav2, S. S. Khetmar2 and M. S. Bhatia*2


RP-HPLC) method has been developed for the simultaneous estimation of Diltiazem hydrochloride and Lovastatin in their tablet formulation. The chromatographic method was standardized using a Kromasil C18 column (300 mm x 4 mm i.d., 10 ?m particle size) with UV detection at 237 nm and flow rate of 1 ml/min. The mobile phase consisting of methanol: water (90:10: v/v). The retention time for the Diltiazem hydrochloride and Lovastatin was found to be 4 min and 5.62 min respectively. Propranolol was selected as an internal standard. Good linearity was obtained for the calibration curve of Diltiazem hydrochloride and Lovastatin and was found to be r2= 0.9925 and r2= 0.9992 respectively. Tablet analysis and recovery results were found to be 99.95?0.79, 99.95?0.79, 99.68?0.34 and 99.65?0.46 for Lovastatin and Diltiazem hydrochloride respectively, where n= 9.


Diltiazem hydrochloride; Lovastatin; Propranolol; RP-HPLC.

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