[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 39(2),
 

Antiproliferative Activity against Various Cancer Cells and Phytochemical Components of Thai Herbal Formula

P. Rungrojtrakool, P. Siripong, J. Yahuafai, W. Chuakul, and R. Temsiririrkkul*

-


Recently, cancer has become a major disease causing death of Thai people. Herbal formulas are complementary choices used for cancer treatment. In this study, a traditional herbal formula, which has been used for lung and liver cancer treatment, was selected from Wang Nam Yen district in Sa Kaeo province. Aqueous extracts of the whole formula and of each component herb were investigated for antiproliferative activity by MTT colorimetric assay against four human cancer cells (KB, MCF-7, HepG2, SiHa) and a non-cancerous cell (Vero). The whole formula extract inhibited growth of hepatocellular carcinoma cell (HepG2) with IC50 value of 347.87 ? 55.06 ?g/ml but showed no activity on other cancer cells. Furthermore, the aqueous extract of phaya fai (Diospyros undulata Well. Ex. G. Don. var. cratericalyx (Craib) Bakh.) and of krajai (Caesalpinia hymenocarpa (Prain) Hattink) showed the most potent antiproliferative effect against all cancer cell lines. Phytochemical screenings of aqueous extracts of the whole formula and of each herb were conducted. Flavonoids and lactone compounds were the major compounds found in the whole formula extract. Whereas, tannins and saponins were also found in each component extract, other anticancer activities and chemical compounds should be studied to consider the mechanism.


Keyword:

Herbal formula, Antiproliferative activity, Stemona collinsiae, Caesalpinia hymenocarpa, Diospyros undulate var. cratericalyx, Celastrus sp.




Download full paper (PDF File size: 2,100.82 KB.)





Vol.39
No.3-4
July - December 2012

See other volume

 


Vol.39
No.2
April - June 2012

See other volume

 


Vol.39
No.1
January - March 2012

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University
Member's menu

You're now loging on with following account:
Guest (unknown)

Please Sign in or Register



    Copyright © 2017
    Faculty of Pharmacy, Mahidol University, THAILAND