[ Pharmaceutical Sciences Asia - ONLINE ]
Print ISSN 2586-8195 E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

Pharm Sci Asia ; 30(3),
 

Percutaneous Absorption Enhancement of Acyclovir

Pojawon Lawanprasert, Sakchai Auychaipornlert, Phongkitti Thisuphakorn, Narong Sarisuta, Busba chindavijak

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Acyclovir is a hydrophilic drug. It can not be permeated well through human skin. A suitable methodology is required for increasing percutaneous absorption of acyclovir to produce the therapeutic level. In this study, it was found that 50%v/v ethanol/ water could enhance the permeability of acyclovir through human epidermis. Enhancing effect of selected enhancers was also studied. It was found that 4%w/v l-menthol showed superior permeability enhancement over capsaicin, nonivamide and methyl salicylate. However, this concentration may cause skin irritation. Other enhancers had less enhancement effect on percutaneous absorption of acyclovir. © All rights reserved.


Keyword:

Percutaneous Absorption ,Acyclovir ,capsaicin, nonivamide ,methyl salicylate








Vol.30
No.3
September-December 2003

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Vol.30
No.2
May-August 2003

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Vol.30
No.1
January-April 2003

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