| DOI: https://doi.org/10.29090/psa.2018.01.045 | Pharm Sci Asia 2018; 45(1), 45-53 |
Evaluation of clenbuterol-induced changes in blood biochemical parameters in white miceN.T.B. Anh, N.T.M. Thuan
- Biochemistry Department of Pharmacy Faculty, University of Medicine and Pharmacy at Ho Chi Minh city, Viet Nam
Clenbuterol is a β2- adrenergic agonist which is illegally used in animal production as a promoting agent. The accumulation of clenbuterol in edible tissues has potentially adversed effects that can induce to long-term metabolism disorders after clenbuterol withdrawal. Purpose of this study is to analysis effects of clenbuterol residues on some blood parameters in white mice. 68 mice were divided into 3 groups: control group (n = 27), clenbuterol groups A (CA) (n = 20) and clenbuterol groups B (CB) (n = 21). Clenbuterol groups were received clenbuterol 2µg/kg orally once daily. After 8 weeks, mice in group A discontinued receiving clenbuterol and mice in group B continued receiving clenbuterol until 16 weeks. Liver, kidney and blood samples were collected at week 8 and week 16 for biochemistry parameter tests: plasma glucose, triglyceride, total cholesterol, total protein, creatinine concentrations; plasma AST and ALT activities. Results showed that oral clenbuterol administration at dosage 2µg/kg once daily for 8 weeks significantly decreased ALT activities and elevated glucose concentrations. Clenbuterol-induced dyslipidemia might reverse after withdrawing using clenbuterol while hyperglycemia might potentially make a progress
Keyword:
clenbuterol, biochemistry parameters, white mice
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