[ Pharmaceutical Sciences Asia - ONLINE ]
E-ISSN 2586-8470
[ Journal Abbreviation: Pharm.Sci.Asia ]
Mahidol University Journal of Pharmaceutical Sciences
  FORMER NAME   "Mahidol University Journal of Pharmaceutical Sciences" Published Since 1974

 
Abstracts

DOI: 10.29090/psa.2018.04.017.0042Pharm Sci Asia 2018; 45(4), 221-230
 

Population pharmacokinetics of meropenem in Vietnamese adult patients

Nguyen Thi Thu Thuy 1, Dinh Duc Thanh 1,2, Ngo Huu Ha 2, Nguyen Thi Lien Huong 1*

1 Department of Clinical Pharmacy, Hanoi University of Pharmacy, Hanoi, Vietnam
2 PhuTho general hospital, PhuTho province, Vietnam


Meropenem is a broad-spectrum antimicrobial frequently used for serious infections. Understanding the pharmacokinetics of meropenem is crucial in optimizing the dosage regimen to treat critically ill patients but there has been no report on its population pharmacokinetic parameters for Vietnamese adult patients. The aim of our study was to develop a population model to describe the pharmacokinetics of meropenem in Vietnamese adult patients. A prospective study was conducted in 30 patients. Plasma meropenem concentrations were measured during the first dose infusion using 6 samples per patient. Concentration-time data were analyzed using a nonlinear mixed-effects modeling approach with MONOLIXSuit2016. Eight participants’ covariates were analyzed to identify their potential influence on meropenem pharmacokinetics. The adequacy of the constructed model was assessed by good-of-fit plots and the precision of the parameters estimated. Data comprised 173 meropenem concentration measurements. A 2-compartment model with zero-order input and first-order elimination showed the best fit for the data. Creatinin clearance and vasopressor use were two influential covariates for clearance: CL (L/h) = 4.74 x exp(0.019 x (CLCR -51 mL/min)) if vasopressor was used and CL (L/h) = 9.97 x exp(0.019 x (CLCR -51 mL/min)) if vasopressor was not used. The intercompartmental clearance (Q), volume of the central compartment (Vc), volume of the peripheral compartment (Vp) were estimated as 36.5 L/h, 9.24 L, 11.7 L, respectively. The inter-individual variability of CL, Q, Vc, Vp were 35.2%, 54.8%, 59.4% and 35.0%, respectively. The additive error was 0.0197 mg/L and the proportional error was 30.9%.


Keyword:

Meropenem; Population pharmacokinetics; Non-linear mixed effects model




Download full paper (PDF File size: 807.16 KB.)





Vol.45
No.4
October - December 2018

See other volume

 


Vol.45
No.3
July - September 2018

See other volume

 


Vol.45
No.2
April - June 2018

See other volume

 


Vol.45
No.1
January - March 2018

See other volume

 
 
 

Home
Aims and Scope
Editorial Board
Publication Ethics
Instruction to Authors
Announcement
All Volumes & Issues
Submit Online
Contact us
   
Search
   
Faculty of Pharmacy Mahidol University
Mahidol University



Pharmaceutical Sciences Asia by Faculty of Pharmacy, Mahidol University, Thailand is licensed under CC BY-NC-ND 4.0

    Copyright © 2017-2024
    Faculty of Pharmacy, Mahidol University, THAILAND
 

We use Cookies

This site uses cookies to personalise your experience and analyse site traffic. By Clicking ACCEPT or continuing to browse the site you are agreeing to our use of cookies.